Hydrogen Water Protects Brain Cells from Oxidative Damage
Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water
Research hubs: Oxidative Stress · Brain & Nervous System
This research was done on cells or tissue in a lab, not in people or animals.

- Evidence type
- Laboratory study (cells or tissue)
- Authors
- T. Kashiwagi, T. Hamasaki, S. Kabayama, M. Takaki, K. Teruya, Y. Katakura, K. Otubo, S. Morisawa, S. Shirahata
- Journal
- ESACT Proceedings
- Year
- 2005
- Study Type
- Cell Culture
- Delivery
- Water (Electrolysis)
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 5 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Electrolyzed water containing tiny particles of hydrogenated metal may help protect brain cells from damage caused by harmful oxygen molecules.
Key Finding
Electrolyzed reduced water suppressed cell death in three types of nerve cells exposed to oxidative stress by lowering harmful reactive oxygen species and preserving mitochondrial function.
Summary
Researchers tested electrolyzed reduced water (ERW)—water processed through electrolysis to contain hydrogen—on nerve cells in laboratory dishes. They exposed the cells to hydrogen peroxide, which causes damage similar to what happens in some brain diseases. The ERW protected the nerve cells from dying by reducing harmful molecules called reactive oxygen species and maintaining the cells' energy-producing structures called mitochondria.
Practical Takeaway
This is early laboratory research in cell cultures only, not in animals or humans, so it cannot yet support any health claims about ERW and brain disease prevention. While the results are interesting, much more research—including animal studies and human trials—would be needed before drawing conclusions about whether ERW could help prevent neurodegenerative diseases.
Abstract (excerpt)
We have proposed an active hydrogen reduced water theory that active hydrogen produced by electrolysis of water is stabilized in the form of hydrogenated metal nanocolloids in electrolyzed reduced water (ERW) and scavenges intracellular reactive oxygen species (ROS). Because various brain diseases…