Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes

K. Otsubo, K. Teruya, S. Kabayama, S. Morisawa, Sanetaka Shirahata, T. Hamasaki, Y. Ishii, Y. Li, Yoshinori Katakura, Z. Gadek

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DOI: 10.1007/978-1-4020-5476-1_15 DOI is the universal ID for this study.

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The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method revealed that ERW and diseases-improvable natural waters such as Nordenau water in Germany and Hita water in Japan were all reduced waters (RWs) which could function as active hydrogen donors and intracellular ROS scavengers. RWs suppressed the activity of protein tyrosine phosphatase (PTP), which inactivates insulin receptor, suggesting their anti-type 2 diabetes effects via redox regulation. The clinical test of 356 diabetes patients drinking Nordenau water in Germany resulted in the improvement of the relevant tests parameters after 6 days, suggesting the correlation of these changes with the fluctuation of ROS levels in their blood.

Publish Year 2007
Country Japan
Rank Positive
Journal Cell Technology for Cell Products
Primary Topic Whole Body
Secondary TopicDiabetes (Type II)
Model Human
Tertiary TopicOxidative Stress
Vehicle Water, Commercial (Nordenau)
pH Alkaline
Application Ingestion