Hydrogen Gas Boosts Fat Burning During Rest in Healthy Women
- Authors
- Pavel Grepl, Michal Botek, Jakub Krejci, Andrew McKune
- Journal
- Medical Gas Research
- Year
- 2025
- DOI
- 10.4103/mgr.MEDGASRES-D-24-00085
- Study Type
- Human
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Czech Republic
- Health Condition
- Metabolic Dysfunction
- Body System
- Metabolic
TL;DR
Breathing in molecular hydrogen for an hour helped increase fat burning in physically active women, especially those with more body fat.
Key Finding
One hour of hydrogen gas inhalation shifted the body toward burning more fat for energy at rest, with the effect being more pronounced in individuals with higher body fat percentages.
Summary
This study tested whether breathing hydrogen gas for one hour would change how the body burns calories and fat. Twenty healthy young women either breathed hydrogen gas or regular air while resting, and researchers measured their metabolism using a special breathing test. The women who breathed hydrogen gas showed signs of burning more fat and less carbohydrate for energy compared to those who breathed regular air, and this effect was stronger in women with higher body fat percentages.
Practical Takeaway
This small study in healthy young women suggests hydrogen inhalation may modestly increase fat oxidation during rest, but the findings are preliminary and limited to a specific population. More research is needed to determine whether this metabolic shift translates to meaningful health benefits, whether it persists with repeated use, or whether it applies to other age groups and fitness levels.
Abstract
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, double-blind, placebo-controlled, crossover design. The study was conducted at Faculty of Physical Culture, Palacký University Olomouc from September 2022 to March 2023. Twenty, physically active female participants aged 22.1 ± 1.6 years who inhaled either molecular hydrogen or ambient air through a nasal cannula (300 mL/min) for 60 minutes while resting were included in this study. Metabolic response was measured using indirect calorimetry. Breath-by-breath data were averaged over four 15-minute intervals. Compared with placebo (ambient air), molecular hydrogen inhalation significantly decreased respiratory exchange ratio and ventilation across all intervals. Furthermore, the change in respiratory exchange ratio was negatively correlated with body fat percentage from 30 minutes onwards. In conclusion, 60 minutes of resting molecular hydrogen inhalation significantly increased resting fat oxidation, as evidenced by decreased respiratory exchange ratio, particularly in individuals with higher body fat percentages.