Hydrogen Gas Shows Promise as New Medical Treatment for Multiple Diseases
Molecular hydrogen: An inert gas turns clinically effective

- Evidence type
- Review or commentary
- Authors
- Sergej M. Ostojic
- Journal
- Annals of Medicine
- Year
- 2015
- PMID
- 25936365
- Study Type
- clinical
- Outcome
- positive
- Peer Reviewed
- Yes
- Cited by
- 45 (OpenAlex, as of November 2026)
- Country
- Serbia
TL;DR
Scientists discovered that a super simple gas called hydrogen (H2) can actually help treat lots of different diseases like diabetes, inflammation, and even cancer, which is pretty surprising since people thought it was just an inert gas that didn't do much. More research is still needed to figure out the best ways to use it and whether it's safe for everyone, but early tests show it really might be a game-changer for medicine.
Key Finding
Recent clinical trials show molecular hydrogen may improve health outcomes across multiple disease categories including metabolic disorders, chronic inflammatory conditions, and cancer.
Summary
This paper reviews clinical research on molecular hydrogen (H2), a gas that has been studied in medicine for about 40 years but has gained more attention recently. The review summarizes findings from clinical trials showing that H2 may help with metabolic diseases (like diabetes), chronic inflammation, and cancer. However, the paper notes that important details are still missing, such as the best doses to use, how to deliver it, potential side effects, and whether it works equally well for all types of patients.
Practical Takeaway
While this review suggests H2 has potential clinical value based on recent trials, it also highlights significant gaps in knowledge about optimal dosing, safety, and which patients benefit most. Anyone considering H2 should be aware that many practical questions about its use remain unanswered, and more research is needed before clear recommendations can be made.
Abstract (excerpt)
Molecular hydrogen (H2) appeared as an experimental agent in biomedicine approximately 40 years ago, yet the past 5 years seem to confirm its medicinal value in the clinical environment. H2 improves clinical end-points and surrogate markers in several clinical trials, from metabolic diseases…