Hydrogen Therapy Shows Promise as New Cellular Protection Treatment
Hydrogen resuscitation, a new cytoprotective approach
Research hubs: Cardiovascular System

- Evidence type
- Review or commentary
- Authors
- Xing-Feng Zheng, Xue-Jun Sun, Zhao-Fan Xia
- Journal
- Clinical and Experimental Pharmacology and Physiology
- Year
- 2011
- PMID
- 21251046
- Study Type
- clinical
- Delivery
- mixed
- Peer Reviewed
- Yes
- Cited by
- 71 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Scientists found that hydrogen gas can protect your cells from damage and help them heal, which could be a new way to treat injuries and diseases caused by harmful chemicals in your body. While this sounds really promising, doctors need to do more research to make sure it actually works in real patients before they can use it as medicine.
Key Finding
Hydrogen demonstrates cytoprotective effects across multiple disease models by selectively eliminating harmful hydroxyl radicals and reducing inflammation, though the precise mechanisms remain incompletely understood.
Summary
This review examines hydrogen as a potential medical treatment, explaining that hydrogen gas may protect cells and tissues from damage caused by oxidative stress (harmful chemical reactions). Hydrogen can be delivered by breathing it in, drinking hydrogen-enriched water, or by increasing the body's natural hydrogen production through diet. Research in animals and cell studies suggests hydrogen may help with conditions like heart attack recovery, inflammation, and metabolic diseases, but human studies are still needed to confirm these benefits.
Practical Takeaway
While early research suggests hydrogen may have protective effects against cellular damage in various disease states, this is a review of mostly animal and laboratory studies—not human clinical trials. Anyone interested in hydrogen therapy should understand that its safety and effectiveness in humans have not yet been established, and more rigorous clinical studies are needed before it can be recommended as a medical treatment.
Abstract (excerpt)
Summary1. Hydrogen is a colourless, odourless, tasteless and flammable gas. Hydrogen is considered a physiologically inert gas and is often used in deep sea diving medicine. In mammals, endogenous hydrogen is produced as a result of the fermentation of non‐digestible carbohydrates by intestinal…