Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water–participation of Pt nanoparticles

Hanxu Yan, Huaize Tian, Kiichiro Teruya, Sanetaka Shirahata, Shigeru Kabayama, Takeki Hamasaki, Tomoya Kinjo

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DOI: 10.1271/bbb.110072 DOI is the universal ID for this study.

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Electrolyzed reduced water (ERW) contains a large amount of molecular hydrogen and a small amount of Pt nanoparticles (Pt NPs). We have found that ERW significantly extended the lifespan of Caenorhabditis elegans in a novel culture medium designated Water Medium. In this study, we found that synthetic Pt NPs at ppb levels significantly extended the nematode lifespan and scavenged reactive oxygen species (ROS) in the nematode induced by paraquat treatment. In contrast, a high concentration of dissolved molecular hydrogen had no significant effect on the lifespan of the nematode. These findings suggest that the Pt NPs in ERW, rather than the molecular hydrogen, extend the longevity of the nematode, at least partly by scavenging ROS.

Publish Year 2011
Country Japan
Rank Positive
Journal Bioscience, Biotechnology, and Biochemistry
Primary Topic Whole Body
Secondary TopicAging
Model Nematode (Caenorhabditis elegans)
Tertiary TopicLife Expectancy
Vehicle Water (Electrolysis)
pH Alkaline
Application Immersion
Complement Platinum