In vivo antiaging effects of alkaline water supplementation

Daniele Macchia, Davide Mizzoni, Mariantonia Logozzi, Massimo Spada, Mauro Andreotti, Rosella Di Raimo, Stefano Fais

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DOI: 10.1080/14756366.2020.1733547 DOI is the universal ID for this study.

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Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. We wanted to investigate the effect of the daily intake of alkaline water on the molecular hallmark of aging and the anti-oxidant response. We watered a mouse model of aging with or without alkaline supplementation. After 10 months, we obtained the blood, the bone marrow and the ovaries from both groups. In the blood, we measured the levels of ROS, SOD-1, GSH, and the telomerase activity and analysed the bone marrow and the ovaries for the telomeres length. We found reduced ROS levels and increased SOD-1, GSH, telomerase activity and telomeres length in alkaline supplemented mice. We show here that watering by using alkaline water supplementation highly improves aging at the molecular level.

Publish Year 2020
Country Italy
Rank Positive
Journal Journal of Enzyme Inhibition and Medical Chemistry
Primary Topic Whole Body
Secondary TopicAging
Model Mouse
Tertiary TopicTelomere Length
Vehicle Water, Commercial (AlkaWater)
pH Alkaline
Application Ingestion