Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model
Hiro-O Ito, Makoto Fukui, Naofumi Tamaki, Rita Cristina Orihuela-Campos
Read more:
DOI:
10.1155/2016/5679040
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed. The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway. The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses.
| Publish Year |
2016 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Oxidative Medicine and Cellular Longevity |
| Primary Topic |
Mouth |
| Secondary Topic | Wound Healing |
| Model |
Rat |
| Tertiary Topic | Oxidative Stress |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Ingestion |
| Comparison |
|
| Complement |
|
Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients ...
2023 - Mouth - Periodontitis
Background: Activated inflammatory cells produce reactive oxygen species (ROS) to eliminate pathogens. Under normal conditions, the pathogens are taken care of, and tissues are repaired. However, in periodontal disease, persistent inflammation causes ...
Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in ...
2021 - Mouth - Periodontitis
Periodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is ...
Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic ...
2021 - Mouth - Periodontitis
Background: Periodontitis is an inflammatory disease causing destruction of tissues surrounding the teeth. The primary etiological factor for periodontitis is plaque. An inference could be drawn that an overall reduction in microorganisms halts ...
Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for ...
2023 - Skin - Wound Healing
Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the ...
Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and ...
2023 - Skin - Wound Healing
Background: Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. ...
Effect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats
2023 - Skin - Wound Healing
Background: Hydrogen has anti-inflammatory and antioxidant effects and is beneficial to multiple organs. However, its effect on alveolar macrophage (AM) pyroptosis induced by burns is still unclear. The purpose of this research was to study the ...