Hydrogen Water Protects Kidneys from Damage After Blood Flow Loss
Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression
- Evidence type
- Animal study (mouse)
- Authors
- Jing Chen, Han Zhang, Jiachang Hu, Yulu Gu, Ziyan Shen, Linghan Xu, Xueqi Jia, Xiaoyan Zhang, Xiaoqiang Ding
- Journal
- Frontiers in Pharmacology
- Year
- 2017
- DOI
- 10.3389/fphar.2017.00499
- Study Type
- Mouse
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Acute Kidney Injury
- Body System
- Urinary System
This research was done in animals. Results in animals often don't carry over to people.
TL;DR
Hydrogen-rich saline (HRS) treatment helps protect against kidney damage and reduces scarring after a kidney injury caused by temporary loss of blood flow and subsequent restoration.
Key Finding
Hydrogen-rich saline reduced kidney scarring and preserved a protective protein called Klotho in mice with acute kidney injury caused by temporary loss of blood flow.
Summary
Researchers tested whether hydrogen-rich saline (salt water containing dissolved hydrogen gas) could protect mouse kidneys from damage caused by temporarily cutting off blood flow and then restoring it. They found that mice treated with hydrogen-rich saline had less scarring in their kidneys, better kidney function, and higher levels of a protective protein called Klotho compared to untreated mice with the same injury.
Practical Takeaway
This early-stage mouse study suggests hydrogen-rich saline may help prevent kidney scarring after acute injury, but much more research is needed before any conclusions can be drawn for human health. The findings are preliminary and limited to laboratory animals, so it's too early to know whether these results would apply to people.
Abstract (excerpt)
Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno-protection of hydrogen-rich saline (HRS) against…