Hydrogen Saline Protects Brain After Stroke in Mouse Study
Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
Research hubs: Brain & Nervous System · Cardiovascular System
- Evidence type
- Animal study (mouse)
- Authors
- Bingjie Jiang, Yunping Li, Weimin Dai, An Wu, Huayong Wu, Dandan Mao
- Journal
- Acta Cirúrgica Brasileira
- Year
- 2021
- DOI
- 10.1590/ACB360804
- Study Type
- Mouse
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Subarachnoid Hemorrhage
- Body System
- Nervous System
This research was done in animals. Results in animals often don't carry over to people.
TL;DR
Hydrogen-rich saline helps mice recover from brain hemorrhage by reducing cell death and stress in brain cells.
Key Finding
Hydrogen-rich saline improved survival rates and neurological recovery in mice with brain bleeding by reducing brain cell death through inhibition of autophagy and endoplasmic reticulum stress.
Summary
Researchers tested hydrogen-rich saline (salt water containing dissolved hydrogen) in mice that had experienced a type of brain bleeding called subarachnoid hemorrhage. They found that the hydrogen treatment improved survival rates, helped mice recover better neurologically, and reduced brain cell death. The protective effect appeared to work by reducing harmful molecules called reactive oxygen species and by preventing excessive autophagy (a cellular self-destruction process) and endoplasmic reticulum stress (a type of cellular damage).
Practical Takeaway
This early-stage mouse study suggests hydrogen-rich saline may have protective effects on the brain after certain types of hemorrhage, but it is not yet clear whether these results would apply to humans. Much more research, including human trials, would be needed before any therapeutic recommendations could be made.
Abstract (excerpt)
Purpose: Subarachnoid hemorrhage (SAH) is a common complication of cerebral vascular disease. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy. Autophagy is a programmed cell death mechanism that plays…