Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage

Bailong Li, Fei Cao, Fu Gao, Jianming Cai, Li-Ren Qian, Shulin Liu, Yuecheng Huang

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DOI: 10.2298/NTRP1001023Q DOI is the universal ID for this study.

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Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Compared to cells pretreated without hydrogen, we demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells. It is concluded that hydrogen has a potential as an effective and safe radioprotective agent.

Publish Year 2010
Country China
Rank Positive
Journal Nuclear Technology and Radiation Protection
Primary Topic Whole Body
Secondary TopicRadioprotection
Model Cell Culture
Tertiary TopicGamma Radiation
Vehicle Medium (Dissolved)
pH Neutral
Application Culture Media