Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage
Read more:
DOI:
10.2298/NTRP1001023Q
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Compared to cells pretreated without hydrogen, we demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells. It is concluded that hydrogen has a potential as an effective and safe radioprotective agent.| Publish Year | 2010 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Nuclear Technology and Radiation Protection |
| Primary Topic | Whole Body |
| Secondary Topic | Radioprotection |
| Model | Cell Culture |
| Tertiary Topic | Gamma Radiation |
| Vehicle | Medium (Dissolved) |
| pH | Neutral |
| Application | Culture Media |
| Comparison | |
| Complement |