New Smart Gas Delivery Systems Target Disease Sites with Precision
- Authors
- Pejman Ghaffari-Bohlouli, Hafez Jafari, Oseweuba Valentine Okoro, Houman Alimoradi, Lei Nie, Guohua Jiang, Ashok Kakkar, Amin Shavandi
- Journal
- Small Methods
- Year
- 2024
- DOI
- 10.1002/smtd.202301349
- Study Type
- clinical
- Peer Reviewed
- Yes
- Country
- Belgium
- Health Condition
- Cancer
- Body System
- Cardiovascular
TL;DR
Scientists found that certain gases like oxygen and nitric oxide can help treat diseases like cancer and heart problems, but they're working on smarter delivery systems that release these gases exactly where they're needed in your body so they help instead of causing harm.
Key Finding
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Summary
Scientists have developed innovative delivery systems for therapeutic gases like hydrogen, oxygen, and others that can target specific disease sites. These smart biomaterial systems respond to body conditions and release gases precisely where needed. This targeted approach reduces the risk of gas poisoning while improving treatment effectiveness. The review covers applications in cancer therapy, cardiovascular disease, bone healing, and wound care. By controlling when and where therapeutic gases are released, these systems represent a significant advance in precision medicine, offering safer and more effective treatments across multiple health conditions.
Abstract
Oxygen (O2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2 S), and hydrogen (H2 ) with direct effects, and carbon dioxide (CO2 ) with complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery and in situ generation of these therapeutic gases with controllable release at the site of disease has attracted attention to avoid the risk of gas poisoning and improve their performance in treating various diseases such as cancer therapy, cardiovascular therapy, bone tissue engineering, and wound healing. Stimuli-responsive gas-generating sources and delivery systems based on biomaterials that enable on-demand and controllable release are promising approaches for precise gas therapy. This work highlights current advances in the design and development of new approaches and systems to generate and deliver therapeutic gases at the site of disease with on-demand release behavior. The performance of the delivered gases in various biomedical applications is then discussed.