New Gas Nanomedicines Use Hydrogen to Fight Cancer Through Immune System
- Authors
- Mengchi Sun, Tianye Wang, Yinmei Zhu, Feng Ling, Jingwen Bai, Chengwu Tang
- Journal
- Biomedicine & Pharmacotherapy
- Year
- 2024
- DOI
- 10.1016/j.biopha.2024.117595
- Study Type
- clinical
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Cancer
- Body System
- Immune System
TL;DR
Scientists are using tiny particles to deliver special gases (like hydrogen) directly into cancer tumors to help the body's immune system fight cancer better. This new approach could be a game-changer for cancer treatment, but doctors still need to figure out the best way to get these gases to work in real patients.
Key Finding
Nanotechnology-based delivery systems for therapeutic gases, particularly hydrogen, show promise for improving cancer immunotherapy by enabling precise tumor targeting and enhanced immune activation.
Summary
This is a review article that examines how certain gases—including hydrogen, nitric oxide, and others—can help fight cancer by activating the immune system. The authors discuss how nanotechnology (extremely tiny particles) can be used to deliver these gases directly to tumors, making the treatment more effective. The review summarizes current research on this approach and identifies challenges that need to be solved before these treatments can be used in patients.
Practical Takeaway
This is a review of existing research rather than a new study with results, so it does not provide direct evidence about hydrogen water or gas therapy effectiveness in humans. While the authors suggest gas-based immune nanomedicines are promising, they note that clinical translation remains a key challenge. Anyone interested in hydrogen-based cancer treatments should await human clinical trials before drawing conclusions.
Abstract
Certain gas molecules, including hydrogen (H2), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), oxygen (O2) and sulfur dioxide (SO2) exhibit significant biological functionalities that can modulate the immune response. Strategies pertaining to gas-based immune therapy have garnered considerable attention in recent years. Nevertheless, delivering various gas molecules precisely into tumors, which leads to enhanced anti-tumor immunotherapeutic effect, is still a main challenge. The advent of gas treatment modality with desirable immunotherapeutic efficiency has been made possible by the rapid development of nanotechnology, which even derives the concept of the gas immnuo-nanomedicines (GINMs). In light of the fact, we herein aim to furnish a cutting-edge review on the latest progress of GINMs. The underlying mechanisms of action for several gases utilized in cancer immunotherapy are initially outlined. Additionally, it provides a succinct overview of the current clinical landscape of gas therapy, and introduces GINMs specifically designed for cancer treatment based on immunotherapeutic principles across multiple strategies. Last but not least, we address the challenges and opportunities associated with GINMs, exploring the potential future developments and clinical applications of this innovative approach.