Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes

H. Hayashi, K. Kusumoto, K. Otsubo, K. Teruya, M. Oda, S. Kabayama, S. Morisawa, Sanetaka Shirahata, T. Hara, T. Maki, Y. Ishii, Y. Katakura

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DOI: 10.1007/0-306-46875-1_90 DOI is the universal ID for this study.

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In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.

Publish Year 1999
Country Japan
Rank Positive
Journal Animal Cell Technology: Products from Cells, Cells as Products
Primary Topic Whole Body
Secondary TopicDiabetes (Type II)
Model Cell Culture
Tertiary TopicGlucose Metabolism
Vehicle Water (Electrolysis)
pH Alkaline
Application Culture Media