Hydrogen Water Protects Kidneys from Damage in Animal Study
- Authors
- Yurii Yevgenivich Rohovyi, Volf Yakovich Tsitrin, Vyacheslav Vasilievich Bilookiy, Michael Ivanovich Sheremet, Oksana Volodimirvna Kolesnik
- Journal
- Journal of Medicine and Life
- Year
- 2022
- DOI
- 10.25122/jml-2022-0155
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Ukraine
- Health Condition
- Acute Kidney Injury
- Body System
- Renal
TL;DR
A hydrogen-rich solution with negative electrical charge protects rat kidneys from damage and inflammation caused by reduced oxygen levels and disrupted energy processes.
Key Finding
Hydrogen-saturated water reduced kidney damage and inflammatory markers in rats with chemically-induced acute kidney injury caused by disrupted cellular energy production.
Summary
Researchers gave rats a special water containing dissolved hydrogen gas while inducing a condition that damages kidney cells by disrupting their energy production. The hydrogen-saturated water reduced kidney damage markers, improved the activity of enzymes that help cells produce energy, and lowered inflammatory chemicals in the blood compared to untreated rats.
Practical Takeaway
This rat study provides early evidence that hydrogen water may have protective effects on kidneys under severe stress conditions, but human studies are needed to determine if these results apply to people. The study used an artificial injury model that may not reflect real-world kidney disease.
Abstract
Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hydroxyl radical and peroxynitrite. In this experiment, we included 60 nonlinear male rats weighing 0.16-0.18 kg and investigated the effect of a negative redox potential solution -297.3±5.27 mV with a molecular hydrogen saturation of 1.2 ppm on the functional-biochemical processes of the kidneys in tissue hypoxia in moderately resistant rats during the separation of oxidation and phosphorylation with the introduction of 2,4-dinitrophenol at a dose of 3 mg/kg. All studies were performed on moderately stable rats. Experimental, functional, biochemical, enzyme-linked immunosorbent, physicochemical, histoenzymochemical, and statistical research methods were used. Under conditions of renal hypoxia in the separation of oxidation and phosphorylation, the use of a solution of negative redox reabsorption of sodium ions in the distal nephron reduces the manifestations of tubular proteinuria, increases the activity of succinate dehydrogenase in the proximal nephron and reduces the redox potential of urine to negative values. Negative redox potential solution with molecular hydrogen saturation has a protective effect on the kidneys and reduces elevated levels of proinflammatory cytokines of tumor necrosis factor-α, interleukin-1-β, and interleukin-6 in blood plasma, and causes oxidative modification of proteins in the renal cortex for their hypoxia in the separation of oxidation and phosphorylation.