Hydrogen-Enriched Dialysis Reduces Oxidative Stress in Kidney Patients
Effect of a hydrogen (<scp><scp>H<sub>2</sub></scp></scp>)‐enriched solution on the albumin redox of hemodialysis patients
Research hubs: Cardiovascular System
- Evidence type
- Controlled trial (non-randomized) · Human study
- Authors
- Hiroyuki Terawaki, Wan‐Jun Zhu, Yukie Matsuyama, Tomoyoshi Terada, Yasuhito Takahashi, Kaoru Sakurai, Shigeru Kabayama, Mariko Miyazaki, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito, Seiichi Era, Masaaki Nakayama
- Journal
- Hemodialysis International
- Year
- 2014
- PMID
- 24274030
- Study Type
- Human
- Participants
- 8
- Delivery
- Solution (Dissolved)
- Dose
- Hydrogen-enriched hemodialysis solution during HD sessions
- H₂ concentration
- 50 ppb H2
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
TL;DR
Adding hydrogen to the solution used in hemodialysis may reduce the harmful oxidative stress experienced by patients during treatment.
Key Finding
Hydrogen-enriched dialysis solutions significantly reduced reversibly oxidized albumin (a marker of oxidative stress) during hemodialysis sessions, whereas standard solutions showed no such reduction.
Summary
This small study looked at whether hydrogen-enriched dialysis solutions could reduce oxidative stress (cellular damage from harmful molecules) in hemodialysis patients. Eight patients underwent two dialysis sessions—one with standard solution and one with hydrogen-enriched solution—and researchers measured stress markers in blood samples. The hydrogen-enriched solution appeared to reduce one specific marker of oxidative stress (reversibly oxidized albumin) during dialysis, while the standard solution did not.
Practical Takeaway
This early human evidence suggests hydrogen-enriched dialysis solutions may help reduce oxidative stress during treatment, which is important because dialysis itself can increase cellular damage. However, this was a very small study (8 patients) with limited duration, so larger and longer studies are needed to confirm whether this translates to real health benefits like fewer cardiovascular problems in dialysis patients.
Abstract (excerpt)
AbstractElevated oxidative stress (OS) is associated with severe cardiovascular disease and premature death among patients treated with hemodialysis (HD). Oxidative stress is enhanced by contact between blood and dialysis membranes during HD sessions. This study aimed to clarify whether hydrogen…