Hydrogen and Carbon Monoxide Gases Protect Kidneys During Surgery
Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury
Research hubs: Cardiovascular System
- Evidence type
- Animal study (rat)
- Authors
- T. Nishida, T. Hayashi, T. Inamoto, R. Kato, N. Ibuki, K. Takahara, T. Takai, Y. Yoshikawa, T. Uchimoto, K. Saito; N. Tanda; J. Kouno; K. Minami; H. Uehara, H. Hirano, H. Nomi, Y. Okada, H. Azuma
- Journal
- Transplantation Proceedings
- Year
- 2018
- DOI
- 10.1016/j.transproceed.2017.12.014
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
- Health Condition
- Ischemia-Reperfusion Injury
- Body System
- Renal
This research was done in animals. Results in animals often don't carry over to people.
TL;DR
Inhaling a mixture of hydrogen and carbon monoxide gases significantly reduces kidney damage caused by temporary loss and restoration of blood flow.
Key Finding
A combination of hydrogen and carbon monoxide gas provided stronger protection against kidney damage from reduced blood flow than hydrogen gas alone in rats, reducing harmful free radicals and inflammatory markers more effectively.
Summary
This rat study tested whether a mixture of hydrogen gas and carbon monoxide gas could better protect kidneys from damage caused by temporarily cutting off blood flow (a condition called ischemia-reperfusion injury). Researchers compared the dual gas mixture to hydrogen gas alone and found that the combination was more effective at reducing harmful molecules called free radicals and decreasing signs of kidney damage and inflammation.
Practical Takeaway
This is an early-stage animal study that suggests hydrogen gas combined with carbon monoxide may have protective effects on kidney tissue during injury. However, this research was conducted only in rats, and it is unclear whether these results would apply to humans or whether inhaling carbon monoxide would be safe in clinical settings. Much more research would be needed before any conclusions could be drawn for human health.
Abstract (excerpt)
Background: Hydrogen (H2) and carbon monoxide (CO) gas are both reported to reduce reactive oxygen species and alleviate tissue ischemia-reperfusion (I-R) injury. The present study was conducted to evaluate the effects of a mixture of H2 gas and CO gas (dual gas) in comparison with hydrogen gas…