Hydrogen Water Improves Toxin Removal During Kidney Dialysis
Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin
Research hubs: Cardiovascular System
- Evidence type
- Laboratory study (cells or tissue)
- Authors
- Yoshihiro Tange, Shingo Takesawa, Shigenori Yoshitake
- Journal
- Nephro-Urology Monthly
- Year
- 2015
- DOI
- 10.5812/numonthly.26847
- Study Type
- Molecular Assay
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
- Health Condition
- Chronic Kidney Disease
- Body System
- Renal
This research was done on cells or tissue in a lab, not in people or animals.
TL;DR
Adding high levels of dissolved hydrogen to dialysis fluid can help remove more of the harmful toxin indoxyl sulfate from the blood.
Key Finding
Dialysate enriched with dissolved hydrogen significantly increased the separation of indoxyl sulfate from albumin in laboratory testing, compared to conventional dialysate.
Summary
This laboratory study tested whether adding extra hydrogen to dialysis fluid (the cleaning solution used in kidney dialysis) could help remove a harmful waste product called indoxyl sulfate that sticks to proteins in the blood. Researchers found that dialysate with high dissolved hydrogen did cause more indoxyl sulfate to separate from albumin (a blood protein) compared to standard dialysate, suggesting this approach might improve how well dialysis removes certain toxins.
Practical Takeaway
This is an early laboratory study, not a human trial, so it cannot yet tell us whether hydrogen-enriched dialysate would actually improve outcomes in dialysis patients. The findings suggest a potential direction for future research, but much more testing—including studies in actual patients—would be needed before this approach could be considered for clinical use.
Abstract (excerpt)
Protein-bound toxins such as indoxyl sulfate (IS) are not efficiently removed by conventional hemodialysis (HD). To improve the removal of IS, we performed an in vitro study to evaluate the effects of high dissolved hydrogen on the dissociation of IS from albumin using simulated HD. Wasted…