Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

Eiji Kobayashi, Jin Endo, Joe Yoshizawa, Junichi Sasaki, Kazuhisa Sugai, Koichiro Homma, Masahiko Fujisawa, Masaru Suzuki, Motoaki Sano, Shizuka Uemura, Tomoyoshi Tamura, Yoji Hakamata, Yoshinori Katsumata

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DOI: 10.1038/s41598-020-77349-8 DOI is the universal ID for this study.

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A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.

Publish Year 2020
Country Japan
Rank Positive
Journal Nature Scientific Reports
Primary Topic Heart
Secondary TopicHigh Blood Pressure
Model Rat
Tertiary TopicHeart Rhythm
Vehicle Gas
pH N/A
Application Inhalation