Hydrogen Therapy Prevents Brain Blood Vessel Spasms After Stroke
- Authors
- Yuan Hong, Songxue Guo, Sheng Chen, Chongran Sun, Jianmin Zhang, Xue-Jun Sun
- Journal
- Journal of Neuroscience Research
- Year
- 2012
- DOI
- 10.1002/jnr.22739
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Subarachnoid Hemorrhage
- Body System
- Neurological
TL;DR
Treating rats with hydrogen-rich saline improved brain health and reduced blood vessel narrowing after a type of stroke caused by bleeding in the brain.
Key Finding
Hydrogen-rich saline treatment significantly improved neurological outcomes and reduced basilar artery vasospasm in rats with experimentally induced subarachnoid hemorrhage, with benefits appearing to stem from reduced oxidative stress and inflammation.
Summary
Researchers studied whether hydrogen-rich saline could help prevent cerebral vasospasm (abnormal narrowing of blood vessels in the brain) that occurs after subarachnoid hemorrhage (bleeding in the space around the brain). In rats with experimentally induced brain bleeding, hydrogen-rich saline treatment improved neurological function and reduced blood vessel narrowing. The treatment appeared to work by reducing harmful molecules called free radicals and decreasing inflammation in blood vessels.
Practical Takeaway
While this rat study suggests hydrogen may help protect against blood vessel complications after brain bleeding, these results cannot yet be applied to humans. Much more research, including human clinical trials, would be needed before hydrogen therapy could be considered a treatment option for this serious condition.
Abstract
AbstractCerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H2) can selectively reduce levels of hydroxyl radicals (·OH) and ameliorate oxidative and inflammatory injuries to organs in many models. However, whether H2 can ameliorate CV after SAH is still unknown. This study was designed to evaluate the efficacy of H2 in preventing SAH‐induced CV. Experimental SAH was induced in Sprague‐Dawley rats using cisterna magna blood injection. Hydrogen‐rich saline (HS) was injected intraperitoneally (5 ml/kg) immediately and at 24 hr after injury. All rats were sacrificed 48 hr after the neurological examination scores had been recorded following SAH. Levels of oxidative stress and inflammation were evaluated. Basilar artery vasospasm was assessed by histological examination using light and transmission electron microscopy. HS treatment significantly improved neurological outcomes and attenuated morphological vasospasm of the basilar artery after SAH. In addition, we found that the beneficial effects of HS treatment on SAH‐induced CV were associated with decreased levels of lipid peroxidation, increased activity of antioxidant enzymes, and reduced levels of proinflammatory cytokines in the basilar artery. These results indicate that H2 has the potential to be a novel therapeutic strategy for the treatment of CV after SAH, and its neuroprotective effect might be partially mediated via limitation of vascular inflammation and oxidative stress. © 2012 Wiley Periodicals, Inc.