All Studies

An Essay on the Medicinal Properties of Factitious Airs: With an Appendix, on the Nature of Blood

Researches, Chemical and Philosophical; Chiefly Concerning Nitrous Oxide, or Dephlogisticated Nitrous Air, and Its Respiration

A Letter to Erasmus Darwin, M.D. on a New Method of Treating Pulmonary Consumption, and Some Other Diseases Hitherto Found Incurable

Rectal insufflation of hydrogen gas: An infallible test in the diagnosis of visceral injury of the gastro-intestinal canal in penetrating wounds of the abdomen

Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas

Hydrogen treatment attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway

Purpose: Spinal cord ischemia-reperfusion injury (SCIRI) can lead to significant losses in sensory and motor functions. The precise role of hydrogen (H2) as an antioxidant in the process of ferroptosis is not fully determined. Materials and methods: This study used an abdominal aorta ligation…

Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice

Molecular hydrogen (H2) exhibits anti-inflammatory and antioxidant properties. However, its role in ultraviolet B (UVB)-induced skin carcinogenesis remains unclear. Male HR-1 hairless mice received continuous H2 (2% hydrogen gas inhalation plus hydrogen-rich water (HRW)) or control treatment…

Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway

Aim: Oxidative stress and chronic inflammation represent two major contributors to slowing the process of diabetic wound healing. So far, there is a lack of characterization of the mechanistic role of hydrogen-rich saline (HRS), despite its antioxidant potential, in diabetic wound repair. This…

Recent Progress in Hydrogen-mediated Neuroprotection via Modulation of Mitochondrial Quality Control Mechanisms in Brain Injury

Brain injury is a leading cause of mortality and long-term disability worldwide, characterized by energy metabolism dysfunction, oxidative stress, inflammatory responses, and programmed cell death, with mitochondrial dysfunction serving as a central pathological nexus. In recent years, hydrogen…

IBS and SIBO: Gut Microbiota, Pathophysiology, and Non-Pharmacological Interventions

Irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) share symptoms such as abdominal pain, bloating, and altered bowel habits. Both are linked to dysbiosis and gut-brain axis dysfunction. IBS is a multifactorial disorder characterized by abnormal motility, visceral…

Innovative oral formulations with silicon nanoparticles for co-delivery of poorly soluble drugs and hydrogen gas

Nanomedicine offers new opportunities for combination therapy by co-delivering multiple active pharmaceutical ingredients (APIs) for improved convenience and synergistic effects. Recently, hydrogen gas (H2) has gained attention for its antioxidant effects suitable for treating a wide variety…

Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?

A recent study published in Redox Biology (Volume 88, December 2025, 103952) demonstrates that molecular hydrogen (H2) rapidly suppresses mitochondrial Complex III activity through a mechanism involving the Rieske iron-sulfur protein (RISP) and subsequent LONP1-dependent proteolysis, challenging…

The Protective Effects of molecular Hydrogen in Sepsis-associated Encephalopathy: current status

Sepsis-associated encephalopathy (SAE) is a severe neurological complication that arises in patients with sepsis, characterised by cognitive impairment and neurological dysfunction. Mechanisms contributing to SAE include oxidative stress, inflammation, mitochondrial dysfunction, and blood-brain…

Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study

Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach…

Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy

Glaucoma-induced optic nerve damage is known to be a leading cause of blindness worldwide, yet current therapies mainly focus on reducing intraocular pressure without paying significant attention to the oxidative stress and inflammation in ocular tissues. Here, we address this issue by developing…

Inflamed vessel–anchored release of H ₂ across the blood-brain barrier for ischemic stroke neuroprotection

Ischemic stroke followed by reperfusion urgently requires safe and efficient cytoprotective strategies, a need still unmet by current pharmacotherapies. Nanotechnology holds promise for improved drug delivery to the brain, yet the efficacy of nanomaterials crossing the blood-brain barrier (BBB)…

A hydrogen-releasing polydopamine palladium hydride nanocoating protects airway mucosal injury induced by endotracheal tube cuff compression

Endotracheal tube (ETT) cuff compression can induce severe airway mucosal injury through ischemia-reperfusion mechanisms, wherein oxidative stress plays a critical pathogenic role. Despite its clinical significance, effective protective strategies remain limited. Here, we developed…

Hydrogen Nanobubbles Inhibit Oxidative Stress and Myocardial Fibrosis to Reverse Chemotherapy-Induced Myocardial Injury

The most severe side effect of chemotherapy is cardiotoxicity, frequently causing myocardial injury characterized by excessive oxidative stress and fibrosis for which effective treatments are lacking. To address this, a hydrogen delivery system, hydrogen nanobubbles (HNBs), was constructed…

Comparative Efficacy of Coral Calcium Carried Hydrogen versus Dexamethasone in a Mouse Model of Allergic Contact Dermatitis

Introduction Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability…

Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes

Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes