All Studies
2,276 studies foundSort & Filter
Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study
Aims: Oxidative stress has recently emerged as a key factor in the pathophysiology of schizophrenia. This study investigated whether inhalation therapy with hydrogen gas, a selective antioxidant, could reduce oxidative stress and improve behavioral outcomes in an MK-801-induced schizophrenia-like…
An Epidemiological Study on the Relationship between Gastric Mucosal Atrophy, Exhaled Hydrogen Concentration, and Gut Microbiota
Introduction: This study aimed to conduct an epidemiological investigation of the relationship between gastric mucosal atrophy and exhaled hydrogen gas concentration, including gut microbiota, in residents who participated in health checkups. Methods: Based on pepsinogen I <70 ng/mL and PG I/PG II…
Molecular Hydrogen Reverses Sepsis-induced Immunoparalysis: Insights from Longitudinal Deep Immunophenotyping
Background/aim: Refractory septic shock and post-cardiac arrest syndrome (PCAS) can induce lethal immunoparalysis. However, longitudinal evidence on the effects of molecular hydrogen on deep human immunophenotyping remains scarce. Case report: We report the case of a 49-year-old man with severe…
Generation and Application of Ultra-Fine, Long-Term Stable Nanobubble Water: An Evaluation of Inclusion Effects on Aromatic Components and Antimicrobial Activity
Nano- and pico-bubble water (NPB), containing hydrogen or ozone, is widely used as a cleaning agent due to its bactericidal and antiviral properties. However, some products-such as certain hydrogen waters-contain only large bubbles or have an extremely low bubble count, making them sometimes…
Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms
Fibromyalgia is a chronic nociplastic pain condition frequently accompanied by affective disturbances, particularly depression, for which effective treatments remain limited. Increasing evidence implicates central oxidative stress, maladaptive synaptic plasticity, and neuroinflammatory alterations…
Hydrogen-Rich Water as a Performance-Enhancing Aid in National-Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
Purpose : We investigated whether a 4-day intake of hydrogen-rich water (HRW) improves finswimming performance and alters physiological and perceptual markers including blood lactate, rating of perceived exertion, and oxidative stress. Methods : Eight females and 4 males, age 21 (5) and 19 (1)…
A hydrogen-releasing polydopamine palladium hydride nanocoating protects airway mucosal injury induced by endotracheal tube cuff compression
Endotracheal tube (ETT) cuff compression can induce severe airway mucosal injury through ischemia-reperfusion mechanisms, wherein oxidative stress plays a critical pathogenic role. Despite its clinical significance, effective protective strategies remain limited. Here, we developed…
Hydrogen-rich water combined with traditional Chinese medicine compound in the treatment of kidney stones: a randomized controlled prospective clinical trial
The formation and development of kidney stones are related to abnormal urine metabolism, oxidative stress and inflammation. Hydrogen-rich water has clear efficacy in antioxidant and improving inflammatory status, while Ye-Shi-Shi-Lin-Formula is a clinically effective traditional Chinese medicine…
Clinical Trial: Randomised Placebo-Controlled Trial of Methylcellulose and Psyllium Gels on Inulin-Induced Colonic Gas
Background: People with irritable bowel syndrome (IBS) often restrict their intake of FODMAPs because of associated gas and abdominal discomfort. Psyllium, a gel-forming fibre, reduces colonic gas after inulin ingestion. Objective: We aimed to determine whether methylcellulose, a low-cost…
H2-driven autonomous pore-forming hydrogel promotes rapid vascularization for dry socket healing
Dry socket (DS) is a stomatological complication after tooth removal when the blood clot gets dislodged. The delayed healing of DS presents a major clinical challenge, primarily because of the angiogenesis impairment. To address this limitation, we developed a dynamic hydrogel hosting functional…
Perioperative Hydrogen Inhalation and Postoperative Pain After Endoscopic Discectomy: A Pilot Non-Randomized Clinical Study with Exploratory Murine Data
Background and Objectives: Postoperative pain after endoscopic discectomy may reflect acute surgical nociception superimposed on pre-existing radicular symptoms. Molecular hydrogen (H2) has antioxidant and anti-inflammatory properties, but clinical evidence for perioperative analgesia is limited…
Innovative oral formulations with silicon nanoparticles for co-delivery of poorly soluble drugs and hydrogen gas
Nanomedicine offers new opportunities for combination therapy by co-delivering multiple active pharmaceutical ingredients (APIs) for improved convenience and synergistic effects. Recently, hydrogen gas (H2) has gained attention for its antioxidant effects suitable for treating a wide variety…
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Combined Molecular Hydrogen and Vitamin C Treatment in Irradiated Normal and Cancer Cell Models: An Exploratory In Vitro Study and Case Reports
Background: Radiation therapy is widely used to treat cancer but frequently causes normal tissue toxicities that compromise patients' quality of life, highlighting the need for strategies that protect healthy tissue without reducing antitumor efficacy. Here, we investigated whether…
Antibacterial and antibiofilm effects of immobilized hydrogen on pathogenic oral bacteria
Aims: Hydrogen, a colorless and odorless gas, possesses various physiological activities, including anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-apoptotic effects. Clinical applications of hydrogen have been investigated in the medical field. However, few studies have…
Post-Ingestion Blood Hydrogen Kinetics Following Oral Hydrogen-Rich Water Intake in Healthy Adults: A Pilot Pharmacokinetic Study
Introduction: Molecular hydrogen (H2) has gained attention as a therapeutic agent due to its antioxidant and anti-inflammatory properties. However, human Pharmacokinetic (PK) data remain limited, particularly for Hydrogen-Rich Water (HRW). This study aimed to characterize blood hydrogen kinetics…
Hydrogen-rich jelly exhibits a positive effect on heart rate variability during orthostatic loading in healthy adults: a randomized crossover trial
Hydrogen gas may improve autonomic regulation. The effects of hydrogen-rich jelly (HRJ) on autonomic responses during postural transition have not yet been investigated. This double-blind, randomized, placebo-controlled crossover trial evaluated HRJ effects on heart rate variability (HRV) in 50…
The role of intestinal gases in pediatric functional constipation: a narrative review of pathophysiology and emerging therapeutics
Pediatric functional constipation (PFC) is a prevalent gastrointestinal disorder affecting approximately 18.2% of children worldwide, characterized by infrequent or painful bowel movements without organic cause, and significantly impairing quality of life, yet its management remains suboptimal…
Hydrogen-Rich Water Effects in Metabolic Syndrome Stratified by Breath Hydrogen
Objectives: Metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. Hydrogen-rich water (HRW) may improve metabolic function, though responses may vary with endogenous hydrogen production. This randomized, double-blind, placebo-controlled trial examined the effects…
Fecal microbiota profiling in patients with irritable bowel syndrome and small intestinal bacterial overgrowth
Small intestinal bacterial overgrowth (SIBO) is common in irritable bowel syndrome (IBS) and has been proposed as an etiologic factor. This study aimed to identify potential fecal microbiota profiles in patients with IBS and SIBO. A total of 52 subjects were enrolled in this study, of whom 18 were…