All Studies

Recent Progress in Hydrogen-mediated Neuroprotection via Modulation of Mitochondrial Quality Control Mechanisms in Brain Injury

Brain injury is a leading cause of mortality and long-term disability worldwide, characterized by energy metabolism dysfunction, oxidative stress, inflammatory responses, and programmed cell death, with mitochondrial dysfunction serving as a central pathological nexus. In recent years, hydrogen…

Precise delivery of medical gases by engineered nanomedicine for enhanced liver fibrosis therapy

Liver fibrosis, a significant global health issue, results from sustained liver injury and is characterized by progressive damage to the liver. Treating liver fibrosis poses considerable challenges due to difficulty in reversal and frequent association with complex, chronic liver injuries…

Targeting the Gut in Sepsis: Therapeutic Potential of Medical Gases

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, often resulting in multiorgan dysfunction. Among affected systems, the gastrointestinal tract plays a central role in sepsis progression by promoting systemic inflammation through impaired barrier…

Hydrogen as a Potential Modulator: Implications for Mast Cell-Sleep-Wake Rhythm-Melatonin Interactions in Sleep Disorders

The pathogenesis of sleep disorders, particularly chronic insomnia, obstructive sleep apnea (OSA), and sleep fragmentation (a symptom within the spectrum of chronic sleep deprivation-related sleep disturbances, rather than an independent diagnostic sleep disorder entity; e.g., as seen comorbidly…

Hypoxic responsiveness and gut fermentation capacity in heart failure patients: preliminary results

Background The gut microbiota has emerged as a key contributor to cardiovascular regulation. Acute stimulation of microbial fermentation with lactulose enhances hypoxic ventilatory response (HVR) in healthy subjects, indicating increased peripheral chemoreceptor (PCh) responsiveness. Given that…

Comments on "Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial"

Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway

Psoriasis is a chronic disease caused by abnormal immune system response, which is characterized by excessive keratinocyte proliferation and the activation of cytokine signaling pathways. In a previous study, we demonstrated in a psoriasis mouse model that hydrogen-rich water, an effective reactive…

Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses

Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain…

Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report

Background/aim Behçet's Disease is a systemic vasculitis affecting both venous and arterial vessels, characterized by painful oral and genital ulcers. Primary Sjögren's Syndrome is an autoimmune disorder mainly targeting exocrine glands, especially the salivary and lacrimal glands, with possible…

Individual variability in hydrogen-producing microbes influences the response to hydrogen supplementation on sleep quality: a randomized, double-blind, placebo-controlled, parallel study

Hydrogen has been reported to exert antioxidant and anti-inflammatory effects, and its potential health benefits have been investigated. However, to our knowledge, evidence regarding its impact on sleep quality in healthy individuals remains extremely limited. In addition, the influence…

The Protective Effects of molecular Hydrogen in Sepsis-associated Encephalopathy: current status

Sepsis-associated encephalopathy (SAE) is a severe neurological complication that arises in patients with sepsis, characterised by cognitive impairment and neurological dysfunction. Mechanisms contributing to SAE include oxidative stress, inflammation, mitochondrial dysfunction, and blood-brain…

Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation

Molecular hydrogen (H2) has selective antioxidant and anti-inflammatory properties, yet its immediate effects on human cerebral oxygenation and autonomic function remain unclear. In this study, we evaluated acute central and autonomic responses to a single 30-minute session of hydrogen inhalation…

The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Background. Medical gases, inhaled nitric oxide (iNO) and molecular hydrogen (iH2), have been used in the therapy for various medical conditions. When combined, these gases have shown to be more effective and safer for patients, and may become a promising treatment option for various diseases…

Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice

Molecular hydrogen has been reported to exert antioxidant and anti-inflammatory effects; however, its impact on inflammation and gut microbiota under aging-associated metabolic stress remains unclear. In this study, we investigated the effects of hydrogen-rich jelly (HRJ) in senescence-accelerated…

Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report

Background/aim: Rhupus syndrome, an overlap of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), is a rare condition characterized by heterogeneous clinical manifestations and difficult management. Conventional therapies, including glucocorticoids, disease-modifying anti-rheumatic…

Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy

ABSTRACT Objective Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study developed a hydrogen‐enriched hyaluronic acid (HA) dressing and aimed to explore its therapeutic effects and mechanisms in DFU treatment. Methods A combination of vacuum‐assisted…

Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity

ABSTRACT Immunogenic cell death (ICD) induced by calcium overload holds great promise for reversing the immunosuppressive tumor microenvironment (TME) and improving cancer immunotherapy. However, achieving sustained calcium dysregulation remains a major challenge. Herein, we report a novel…

Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial

Background: Acute high-intensity exercise induces transient inflammatory and oxidative stress responses, mediated by redox-sensitive signaling pathways and reflected by elevations in interleukin-6 (IL-6) and lipid peroxidation products. Modulation of these responses through hydration-based redox…

Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?

A recent study published in Redox Biology (Volume 88, December 2025, 103952) demonstrates that molecular hydrogen (H2) rapidly suppresses mitochondrial Complex III activity through a mechanism involving the Rieske iron-sulfur protein (RISP) and subsequent LONP1-dependent proteolysis, challenging…

Microenvironment-responsive piezoelectric nanoreactors integrate O2 and H2 generation for efficient tumor sonodynamic therapy

Sonodynamic therapy (SDT) has emerged as a research hotspot in tumor therapy due to its non-invasiveness, non-toxicity and high penetrability, as it activates sonosensitizers to generate reactive oxygen species (ROS) for tumor cell ablation under ultrasound irradiation. However, its therapeutic…