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Anti-injury effect of hydrogen-enriched water in a rat model of liver injury induced by aflatoxin B1
The purpose of this study was to investigate the anti-injury effect and protective mechanism of hydrogen-enriched water in a rat model of acute liver injury induced by aflatoxin B1 (AFB1). Healthy male Sprague-Dawley (SD) rats were randomly divided into control group, model group (AFB1 group)…
Medical Application of Hydrogen in Hematological Diseases
Hydrogen gas has been reported to have medical efficacy since the 1880s. Still, medical researchers did not pay much attention to hydrogen gas until the 20th century. Recent research, both basic and clinical, has proven that hydrogen is an important physiological regulatory factor…
Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies
The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough has been hitherto achieved with this tumor…
Recent advances in the neuroprotective effects of medical gases
Central nervous system injuries are a leading cause of death and disability worldwide. Although the exact pathophysiological mechanisms of various brain injuries vary, central nervous system injuries often result in an inflammatory response, and subsequently lead to brain damage. This suggests that…
Hydrogen Gas from Inflammation Treatment to Cancer Therapy
Hydrogen (H2) therapy is a highly promising strategy against several diseases due to its inherent biosafety. However, the current H2 treatment modalities rely predominantly on the systemic administration of the gas, resulting in poor targeting and utilization. Furthermore, although H2 has…
Progress in the Use of Molecular Hydrogen for Cancer Treatment
Molecular hydrogen is an effective antioxidant. Numerous studies have demonstrated the therapeutic effects of hydrogen in the treatment of various human diseases. The possibility of using hydrogen in the treatment of cancer was first discovered in 1975, and in recent studies, researchers have…
Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic…
Micro/Nanomaterials-Augmented Hydrogen Therapy
Abstract Hydrogen therapy is an emerging and promising therapy strategy of using molecular hydrogen as a new type of safe and effective therapeutic agent, exhibiting remarkable therapeutic effects on many oxidative stress‐/inflammation‐related diseases owing to its bio‐reductivity and homeostatic…
Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases
Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, inflammation, and cancer. All these pathological…
The role of medical gas in stroke: an updated review
Medical gas is a large class of bioactive gases used in clinical medicine and basic scientific research. At present, the role of medical gas in neuroprotection has received growing attention. Stroke is a leading cause of death and disability in adults worldwide, but current treatment is still very…
Antioxidant Effect of Hydrogen Nanobubble Contributes to Suppression of Tumor Cell Growth
The antitumor effect of hydrogen nanobubble was evaluated in vitro and in vivo. Cancer cell growth was inhibited in the hydrogen nanobubble-containing medium compared to the non-containing medium (in vitro). Tumor growth was significantly suppressed in the middle stage of transplantation (in vivo)…
The combination of alkaline water provision and asthma-induced gymnastics towards peak expiratory flow rate of asthma patients at Surakarta Lung Clinic, Indonesia
Background: Asthma is an abnormality in the form of chronic airway inflammation which can be reduced by providing asthma-induced gymnastics and healthy lifestyle such as consuming alkaline water.Aims: The objective of this study is to examine a combination of alkaline water provision…
Hydrogen inhalation protects hypoxic–ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats
Hypoxic–ischemic brain damage (HIBD) is one of the leading causes of brain injury in infant with high risk of mortality and disability; therefore, it is important to explore more feasible and effective treatment strategies. Here, we assessed the neuroprotective effects of different hydrogen…
Effects of hydrogen-rich water in a rat model of polycystic kidney disease
Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that…
Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner
Sepsis-induced hepatic dysfunction is considered as an independent risk factor of multiple organ dysfunction syndrome (MODS) and death. Mitophagy, a selective form of autophagy, plays a major role in sepsis-induced organ damage. We have demonstrated that hydrogen gas (H2), a selective antioxidant…
Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R�injury via PINK-mediated autophagy
Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen…
MicroRNA Files in the Prevention of Intestinal Ischemia/Reperfusion Injury by Hydrogen Rich Saline
Abstract Background: Hydrogen-rich saline (HRS) has been proven effective against ischemia/reperfusion (I/R) injury. However, knowledge on the underlying signaling events remain poor. Having recent highlight of microRNAs (miRNAs) in mediating intestinal I/R injury, we hypothesized that HRS may…
The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats
This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm)…
Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial
Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance…
The effects of hydrogen-rich saline solution on intestinal anastomosis performed after intestinal ischemia reperfusion injury
Aim We investigated the effects of hydrogen-rich saline solution (HRSS) on intestinal anastomosis performed after intestinal ischemia reperfusion injury (IRI). Materials and methods Thirty Wistar albino female rats were randomly divided into five groups. Only laparotomy was performed in the Sham…