Hydrogen Solution May Improve Intestinal Healing After Surgery in Rats
The effects of hydrogen-rich saline solution on intestinal anastomosis performed after intestinal ischemia reperfusion injury
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Sibel Eryilmaz, Zafer Turkyilmaz, Ramazan Karabulut, Merve Altin Gulburun, Aylar Poyraz, Ozlem Gulbahar, Burak Arslan, Kaan Sonmez
- Journal
- Journal of Pediatric Surgery
- Year
- 2019
- PMID
- 31466816
- Study Type
- Rat
- Participants
- 30
- Delivery
- Saline (Dissolved)
- Dose
- 5 ml/kg intraperitoneally before reperfusion and for four more days
- Duration
- 5 days
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 19 (OpenAlex, as of November 2026)
- Country
- Turkey
TL;DR
Hydrogen-rich saline solution (HRSS) helps reduce damage and improve healing in rat intestines after blood flow is temporarily cut off and restored.
Key Finding
Hydrogen-rich saline solution reduced intestinal tissue damage and cell death while improving the strength of surgical intestinal connections in rats recovering from ischemia reperfusion injury.
Summary
Researchers tested whether hydrogen-rich saline solution could protect the intestines in rats that experienced a temporary loss of blood flow (ischemia reperfusion injury) followed by surgical connection of the intestine (anastomosis). Rats given hydrogen-rich saline showed less tissue damage, lower cell death, and stronger surgical connections compared to untreated rats, though some chemical markers did not differ significantly between groups.
Practical Takeaway
This rat study suggests hydrogen-rich saline may help protect intestinal tissue after blood flow loss and surgery, but the findings are preliminary and have not been tested in humans. More research is needed before any conclusions can be drawn about potential benefits for surgical patients.
Abstract (excerpt)
Aim We investigated the effects of hydrogen-rich saline solution (HRSS) on intestinal anastomosis performed after intestinal ischemia reperfusion injury (IRI). Materials and methods Thirty Wistar albino female rats were randomly divided into five groups. Only laparotomy was performed in the Sham…