All Studies

A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics

Despite all efforts, the treatment of breast cancer (BC) cannot be considered to be a success story. The advances in surgery, chemotherapy and radiotherapy have not been sufficient at all. Indeed, the accumulated experience clearly indicates that new perspectives and non-main stream approaches…

A New Approach for the Prevention and Treatment of Cardiovascular Disorders: Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

Cardiovascular diseases are the most common causes of morbidity and mortality worldwide. Redox dysregulation and a dyshomeostasis of inflammation arise from, and result in, cellular aberrations and pathological conditions, which lead to cardiovascular diseases. Despite years of intensive research…

Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19

Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients

Hydrogen has been shown to have antioxidant, anti-inflammatory, hormone-regulating, and apoptosis-resistance properties, among others. Based on a review of the research, the use of hydrogen might reduce the destructive cytokine storm and lung injury caused by SARS-CoV-2 during COVID-19 (Corona…

Administration of inhaled noble and other gases after cardiopulmonary resuscitation: A systematic review

Objective: Inhalation of noble and other gases after cardiac arrest (CA) might improve neurological and cardiac outcomes. This article discusses up-to-date information on this novel therapeutic intervention. Data sources: CENTRAL, MEDLINE, online published abstracts from conference proceedings…

Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment on body fluid balance and exercise performance

Electrolyzed hydrogen water (EHW) is generated at a cathode. It contains many hydrogen molecules with high alkaline properties. The physiological effects of ingesting EHW during endurance exercise are unclear. The purpose of this study was to determine the effects of ingesting EHW during endurance…

Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation…

Hydrogen plays a protective role in intestinal injury of mice with severe sepsis by regulating the release of heme oxygenase-1 and high mobility group protein B1

Objective: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway. Methods: The 280 male wild-type (WT)…

Role of Hydrogen in Atherosclerotic Disease: From Bench to Bedside

Atherosclerotic cardiovascular and cerebrovascular diseases are among the leading causes of morbidity and mortality worldwide. Given our recent understanding of its role as a small-molecule antioxidant and anti- inflammatory agent, hydrogen may play an important role in preventing and treating…

The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in athletes

In the double-blind study, the effect of drinking Hydrogen-Rich Water (HRW) producing by alkaline stick and tap water (placebo) on 9 male athletes in resistance training during 24 h were studied, and Lactate Dehydrogenase (LDH), Creatine Kinase (CPK) and Lactic Acid (LAC) levels in their blood…

Effect of ionised (electrolysed) water on the rat embryo development

The aim of this study was to investigate the effects ionised water has on embryonic development using Wistar rat animal model. For that purpose, alkaline and acidic water was prepared with a domestic water ioniser. It was found that the concentrations of Cl–, SO42– ions increased in acidic water…

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis

Our previous study found that hydrogen gas (H2) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. The present study aimed to explore the roles of H2 in lung cancer cell autophagy, and reveal the effects of autophagy on H2-mediated…

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Molecular hydrogen (H 2 ) is a colorless, tasteless, odorless, and minimal molecule with high flammability. Although H 2 has been thought to be an inert gas in living bodies for many years, an animal study reported that inhalation of H 2 gas decreased oxidative stress and suppressed brain injury…

Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng (KRG) water (HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young (3 month-old) and aged (12 month-old) male mice were randomly assigned to 4 groups (n =10 per group)…

Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities

Background: Hydrogen gas (H2) has entered the world of experimental therapeutics approximately four and a half decades ago. Over the years, this simple molecule appears to drive more scientific attention, perhaps due to a dualism of H2 affirmative features demonstrated in numerous in vitro, animal…

Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation

Physical exercise-induced oxidative stress and inflammation may be beneficial when exercise is a regular activity, but it is rather harmful when exercise is exhaustive and performed by unaccustomed organisms. Molecular hydrogen (H2 ) has recently appeared as a potent antioxidant…

Application of Hydrogen in Ophthalmology

This report reviews studies on the use of H2 in the ophthalmological field. In retinal diseases, particularly in a retinal ischemia-reperfusion injury, effects of H2 are remarkable in reducing retinal tissue damage. H2 treatment of corneal damage caused by alkali or UVB suppressed scar formation…

Molecular hydrogen (H₂) as a potential treatment for acute and chronic fatigue

Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID-19 and chronic diseases like Parkinson's…

Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial

Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems

The increased production of reactive oxygen species and oxidative stress are important factors contributing to the development of diseases of the cardiovascular and central nervous systems. Molecular hydrogen is recognized as an emerging therapeutic, and its positive effects in the treatment…