All Studies
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A hydrogen-releasing polydopamine palladium hydride nanocoating protects airway mucosal injury induced by endotracheal tube cuff compression
Endotracheal tube (ETT) cuff compression can induce severe airway mucosal injury through ischemia-reperfusion mechanisms, wherein oxidative stress plays a critical pathogenic role. Despite its clinical significance, effective protective strategies remain limited. Here, we developed…
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation
Molecular hydrogen (H2) has selective antioxidant and anti-inflammatory properties, yet its immediate effects on human cerebral oxygenation and autonomic function remain unclear. In this study, we evaluated acute central and autonomic responses to a single 30-minute session of hydrogen inhalation…
Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial
Background: Acute high-intensity exercise induces transient inflammatory and oxidative stress responses, mediated by redox-sensitive signaling pathways and reflected by elevations in interleukin-6 (IL-6) and lipid peroxidation products. Modulation of these responses through hydration-based redox…
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy
ABSTRACT Objective Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study developed a hydrogen‐enriched hyaluronic acid (HA) dressing and aimed to explore its therapeutic effects and mechanisms in DFU treatment. Methods A combination of vacuum‐assisted…
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Molecular hydrogen (H2) exhibits anti-inflammatory and antioxidant properties. However, its role in ultraviolet B (UVB)-induced skin carcinogenesis remains unclear. Male HR-1 hairless mice received continuous H2 (2% hydrogen gas inhalation plus hydrogen-rich water (HRW)) or control treatment…
Inflamed vessel–anchored release of H <sub>2</sub> across the blood-brain barrier for ischemic stroke neuroprotection
Ischemic stroke followed by reperfusion urgently requires safe and efficient cytoprotective strategies, a need still unmet by current pharmacotherapies. Nanotechnology holds promise for improved drug delivery to the brain, yet the efficacy of nanomaterials crossing the blood-brain barrier (BBB)…
Hydrogen treatment attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway
Purpose: Spinal cord ischemia-reperfusion injury (SCIRI) can lead to significant losses in sensory and motor functions. The precise role of hydrogen (H2) as an antioxidant in the process of ferroptosis is not fully determined. Materials and methods: This study used an abdominal aorta ligation…
Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study
Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach…
Efficacy of silicon-based agent against aging-related frailty
Increasing aging populations globally have made maintaining a healthy life expectancy for older adults a critical issue. Older adults are particularly susceptible to frailty, physical and mental vulnerability caused by age-related decline in physiological and psychological resilience. Preventing…
Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice
Molecular hydrogen has been reported to exert antioxidant and anti-inflammatory effects; however, its impact on inflammation and gut microbiota under aging-associated metabolic stress remains unclear. In this study, we investigated the effects of hydrogen-rich jelly (HRJ) in senescence-accelerated…
Hydrogen Nanobubbles Inhibit Oxidative Stress and Myocardial Fibrosis to Reverse Chemotherapy-Induced Myocardial Injury
The most severe side effect of chemotherapy is cardiotoxicity, frequently causing myocardial injury characterized by excessive oxidative stress and fibrosis for which effective treatments are lacking. To address this, a hydrogen delivery system, hydrogen nanobubbles (HNBs), was constructed…
Selective Antimicrobial Activity of Slightly Acidic Electrolyzed Water: Differential Effects on Harmful and Beneficial Bacteria in Microbial Fermentation Systems
Microbial contamination in fermentation systems poses significant risks to safety and efficiency, as harmful microbes can proliferate while conventional disinfectants often indiscriminately harm beneficial lactic acid bacteria (LAB). This study investigated the selective antimicrobial activity…
Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway
Aim: Oxidative stress and chronic inflammation represent two major contributors to slowing the process of diabetic wound healing. So far, there is a lack of characterization of the mechanistic role of hydrogen-rich saline (HRS), despite its antioxidant potential, in diabetic wound repair. This…
Recent Progress in Hydrogen-mediated Neuroprotection via Modulation of Mitochondrial Quality Control Mechanisms in Brain Injury
Brain injury is a leading cause of mortality and long-term disability worldwide, characterized by energy metabolism dysfunction, oxidative stress, inflammatory responses, and programmed cell death, with mitochondrial dysfunction serving as a central pathological nexus. In recent years, hydrogen…
Comparative Efficacy of Coral Calcium Carried Hydrogen versus Dexamethasone in a Mouse Model of Allergic Contact Dermatitis
Introduction Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability…
Molecular hydrogen in cancer therapy: Bioactive materials for tumor-targeted delivery and in situ generation
Molecular hydrogen (H2) therapy has emerged as a promising adjunctive strategy in oncology, primarily attributed to its selective antioxidant, anti-inflammatory, and cytoprotective properties. Advances have been driven by the integration of mechanistic studies on H2-mediated redox regulation…
Clinical Trial: Randomised Placebo-Controlled Trial of Methylcellulose and Psyllium Gels on Inulin-Induced Colonic Gas
Background: People with irritable bowel syndrome (IBS) often restrict their intake of FODMAPs because of associated gas and abdominal discomfort. Psyllium, a gel-forming fibre, reduces colonic gas after inulin ingestion. Objective: We aimed to determine whether methylcellulose, a low-cost…
Hydrogen-rich water combined with traditional Chinese medicine compound in the treatment of kidney stones: a randomized controlled prospective clinical trial
The formation and development of kidney stones are related to abnormal urine metabolism, oxidative stress and inflammation. Hydrogen-rich water has clear efficacy in antioxidant and improving inflammatory status, while Ye-Shi-Shi-Lin-Formula is a clinically effective traditional Chinese medicine…
Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice
Aims: Acute aortic dissection (AAD) is a life-threatening condition in which vascular inflammation contributes to disease progression and complications such as aortic rupture. Current treatment is centered on hemodynamic control, and anti-inflammatory options remain limited. We investigated whether…
Preventable in-body hydrogen explosions from high-concentration H2 inhalers in Japan-Switch to safe, low-concentration hydrogen therapy
BackgroundWith the growing recognition of the medical applications of hydrogen, hydrogen gas inhalers are increasingly used in clinics and other healthcare settings. However, hydrogen is highly explosive, and numerous explosion incidents involving these inhalers have been reported.ObjectivesThis…