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Studies Found: 590

LIVER - HEPATITIS B

Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with ...

Year Published: 2013

Objective: To investigate effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB). Methods: Sixty patients with CHB were randomly assigned into routine treatment group or hydrogen treatment group in which patients received routine treatment alone or additional oral HRW (1200-1800 mL/day, twice daily), respectively, for 6 ...
PERITONIUM - PERITONEAL DIALYSIS

Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel ...

Year Published: 2013

Background: Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS ...
BONE - SPACEFLIGHT

Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled ...

Year Published: 2013

Treatment with molecular hydrogen alleviates microgravity-induced bone loss through abating oxidative stress, restoring osteoblastic differentiation, and suppressing osteoclast differentiation and osteoclastogenesis. Introduction: Recently, it has been suggested that hydrogen gas exerts a therapeutic antioxidant activity by selectively reducing cytotoxic reactive oxygen species (ROS). The aim of ...
WHOLE BODY - AGING

Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via ...

Year Published: 2013

Electrolyzed-reduced water (ERW) scavenges reactive oxygen species and is a powerful anti-oxidant. A positive correlation between oxidative stress and aging has been proved in many model organisms. In Caenorhabditis elegans, many long-lived mutants showed reduced fertility as a trade off against longevity phenotype. We aimed to study the effect of ERW on oxidative stress, fertility and lifespan of ...
EYE - DIABETES

Hydrogen-Rich Saline Prevents Early Neurovascular Dysfunction Resulting from Inhibition of Oxidative ...

Year Published: 2013

Purpose: Diabetic retinopathy (DR) is characterized by increased oxidative and nitrosative stress, both of which lead to neurotoxicity and vascular permeability. Previous studies on a variety of organs indicate that hydrogen-rich saline not only has considerable antioxidant and anti-inflammatory properties, but also suppresses oxidative stress-induced injury. In the present study, we assessed the ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

Year Published: 2013

Background: Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). Methods: ...
PREGNANCY - PREECLAMPSIA

Regulative effect of hydrogen on oxidative stress level of placental ischemia-reperfusion cell model ...

Year Published: 2014

Objective To investigate the effects of hydrogen on cell protection of placental ischemia-reperfusion cell model of preeclampsia and its possible mechanism. Methods JAR cells cultured in vitro were divided into five groups, i.e. the blank control group, saturated hydrogen group under normal oxygen cultivation conditions (normal oxygen+H2 group), ischemia-reperfusion model group (model group), ...
LIVER - SURGERY/TRANSPLANTATION

Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing ...

Year Published: 2014

The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI. Hydrogen enriched ...
BRAIN - TRAUMATIC BRAIN INJURY

Attenuation of diffuse axonal injury by intraperitoneal injection of hydrogen via reducing oxidative ...

Year Published: 2014

To investigate the role of oxidative stress in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI models. Methods Totally 118 adult male SD rats were divided into 3 groups with 39 in each: sham, DAI, and DAI + hydrogen treatment. Rat diffuse axonal injury was induced by an experimental facility, which was developed to make the rat head spin 90 degrees at the moment to cause ...
BRAIN - SEPSIS

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via ...

Year Published: 2014

During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes and effective therapeutic strategies of brain injury in sepsis are still not fully clear. We designed this ...
TESTES - ENVIRONMENTAL POLLUTION

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine ...

Year Published: 2014

The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice. The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive system and testicular oxidative levels in nicotine-treated (4.5 mg/kg, s.b.) mice were investigated. It ...
LIVER - LIVER DISEASE

Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and ...

Year Published: 2014

AimIn cirrhosis, increased oxidative stress leads to systemic and splanchnic hyperdynamic circulation, splanchnic angiogenesis, portosystemic collaterals formation, hepatic endothelial dysfunction, increased intrahepatic resistance, and the subsequent portal hypertension. Like N-acetylcysteine, hydrogen-rich saline is a new documented antioxidant with the potential to treat the complications of ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with ...

Year Published: 2015

Objective: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Methods: Ninety healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI group and hydrogen rich water treatment group (HW group), with 30 rats in each group. TBI model ...
EYE - RETINAL INJURY

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived ...

Year Published: 2015

Background Oxidative and nitrative processes have an important role in the pathogenesis of glaucomatous neurodegeneration. Oxidative stress occurs when cellular production of reactive oxygen species outweighs the protective capacity of antioxidant defences. Reactive oxygen species are generated as by-products of cellular metabolism, primarily in the mitochondria. Herein, we present a novel ...
WHOLE BODY - EXCERCISE

Intravenous infusion of H2-saline suppresses oxidative stress and elevates antioxidant potential in ...

Year Published: 2015

Upon intensive, exhaustive exercise, exercise-induced reactive oxygen species may exceed the antioxidant defence threshold, consequently resulting in muscular damage or late-onset chronic inflammation. Recently, the therapeutic antioxidant and anti-inflammatory effects of molecular hydrogen (H2) for human rheumatoid arthritis have been demonstrated. However, it is also important to clarify the ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing ...

Year Published: 2015

Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and ...
KIDNEY - KIDNEY STONES

Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal ...

Year Published: 2015

The aim of this study is to evaluate the protective effect and underlying mechanism of hydrogen gas (H2) to glyoxylate induced renal calcium oxalate (CaOx) crystal deposition in mice. In present work, rodent renal CaOx crystal deposition model was introduced by intra-abdominal injection of glyoxylate (100 mg/kg/d) for 5 days. Two days before administration of glyoxylate, inhalation of H2 for 30 ...
OVARIES - CANCER

Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative ...

Year Published: 2015

Hydrogen has been reported to exert a therapeutic effect in several diseases due to its antioxidative, antiinflam-matory and anti-apoptotic properties. The aim of the present study was to investigate whether hydrogen-rich saline treatment could attenuate ovarian damage induced by cisplatin. A total of 240 adult, virgin, female Sprague Dawley rats, weighing 180-220 g, were randomly divided into ...
PANCREAS - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas ...

Year Published: 2015

Purpose: This study aimed to investigate the therapeutic potential of hydrogen-rich saline on pancreatic ischemia/reperfusion (I/R) injury in rats. Methods: Eighty heterotopic pancreas transplantations (HPT) were performed in syngenic rats. The receptors were randomized blindly into the following three groups: the HPT group and two groups that underwent transplantation and administration of ...
EYE - RETINAL INJURY

Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and ...

Year Published: 2015

Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia‑reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen‑rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP‑1 activation. RIR was induced by ...
BONE - OSTEONECROSIS

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of ...

Year Published: 2015

A growing body of evidence suggests that hydrogen is a novel, selective antioxidant that exerts a protective effect against organ damage. The present study investigated the effect of hydrogen-rich saline on corticosteroid‑induced necrosis of the femoral head in an animal model established using prednisolone. A total of 30 healthy, male, adult New Zealand white rabbits were randomly divided into ...
KIDNEY - ACUTE KIDNEY INJURY

Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing ...

Year Published: 2015

Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats. Severe burn were induced via immersing the shaved back of rats into ...
BONE - RHEUMATOID ARTHRITIS

Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative ...

Year Published: 2016

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, we examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, we evaluated the effect of hydrogen on RA-FLSs development and the expression of ...
MUSCLE - EXCERCISE

Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness

Year Published: 2016

Several studies have reported that molecular hydrogen (H2) acts as a therapeutic medical gas owing to scavenging reactive oxygen species (ROS). However, little is known about effects of H2 on exercise-induced oxidative stress. The purpose of this study was to investigate the effects of weekly hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness (DOMS). Nine ...
LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress ...

Year Published: 2017

Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydrogen (H2) may ameliorate oxidative stress injuries by selectively neutralizing ...