Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

DanDan Lu, Shu Li, Yaling Zhang, Yi Zhang

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DOI: 10.1007/s10815-013-0102-2 DOI is the universal ID for this study.

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The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice. The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive system and testicular oxidative levels in nicotine-treated (4.5 mg/kg, s.b.) mice were investigated. It was found that vitamin C and vitamin E attenuated serum oxidative level, but did not lower testicular oxidative levels in mice subjected to chronic nicotine treatment, and did not improve the male reproductive damage and apoptosis induced by nicotine. Different from normal antioxidants, vitamin C and vitamin E, hydrogen-rich saline abated oxidative stress in testis, and protected against nicotine-induced male reproductive damages. Our results first demonstrated that long-term treatment with hydrogen-rich saline attenuated testicular oxidative level and improved male reproductive function in nicotine-treated mice.

Publish Year 2014
Country China
Rank Positive
Journal Journal of Assisted Reproduction and Genetics
Primary Topic Testes
Secondary TopicEnvironmental Pollution
Model Mouse
Tertiary TopicCigarette Smoke Exposure
Vehicle Saline (Dissolved)
pH Neutral
Application Injection