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Studies Found: 256

MUSCLE - SURGERY/TRANSPLANTATION

Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in ...

Year Published: 2015

Despite the application of nerve grafts and considerable microsurgical innovations, the functional recovery across a long peripheral nerve gap is generally partial and unsatisfactory. Thus, additional strategies are required to improve nerve regeneration across long nerve gaps. Hydrogen possesses antioxidant and anti-apoptotic properties, which could be neuroprotective in the treatment of ...
BRAIN - AMYOTROPHIC LATERIAL SCLEROSIS

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic ...

Year Published: 2015

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and accumulating evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed well in clinical trials. The aim of this work was to investigate the effect of treatment with hydrogen molecule on the development of disease in mutant SOD1 G93A transgenic ...
BRAIN - STROKE

Role of FOXO3A in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion ...

Year Published: 2015

To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats. Seventy-two male Sprague Dawley rats, weighing 280-320 g, were randomly divided into six groups (n = 12 each) : sham operation group (group I), cerebral ischemia-reperfusion group (group II), hydrogen-rich saline group (group III), vehicle group (group IV), ...
WHOLE BODY - HYDROGEN BIOLOGY

Estimation of the hydrogen concentration in rat tissue using an airtight tube following the ...

Year Published: 2015

Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical and therapeutic applications in the clinical setting. In the present study, the hydrogen concentration in rat blood and tissue was estimated. Wistar rats were orally administered hydrogen ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline attenuates neuronal ischemia – Reperfusion injury by protecting ...

Year Published: 2014

Background: Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia–reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
BRAIN - NEUROPATHIC PAIN

Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of ...

Year Published: 2014

Background Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced analgesia. Methodology/Principal findings In a rat model of neuropathic pain induced by L5 spinal ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of ...

Year Published: 2014

Background: We have previously shown that hydrogen (H2) inhalation, begun at the start of hyperoxic cardiopulmonary resuscitation, significantly improves brain and cardiac function in a rat model of cardiac arrest. Here, we examine the effectiveness of this therapeutic approach when H2 inhalation is begun on the return of spontaneous circulation (ROSC) under normoxic conditions, either alone or in ...
BRAIN - BRAIN INJURY

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early ...

Year Published: 2014

Backgrounds: Early brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However, the molecular mechanism underlying hydrogen-mediated anti-apoptotic effects in SAH has not been elucidated. In the present study, we aimed to ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and ...

Year Published: 2014

Background: Sudden cardiac arrest is a leading cause of death worldwide. Three-fourths of cardiac arrest patients die before hospital discharge or experience significant neurological damage. Hydrogen-rich saline, a portable, easily administered, and safe means of delivering hydrogen gas, can exert organ-protective effects through regulating oxidative stress, inflammation, and apoptosis. We ...
BRAIN - AGING

Electrochemically reduced water protects neural cells from oxidative damage

Year Published: 2014

Aging-related neurodegenerative disorders are closely associated with mitochondrial dysfunction and oxidative stresses and their incidence tends to increase with aging. Brain is the most vulnerable to reactive species generated by a higher rate of oxygen consumption and glucose utilization compared to other organs. Electrochemically reduced water (ERW) was demonstrated to scavenge reactive oxygen ...
BRAIN - NEUROPATHIC PAIN

Molecular hydrogen attenuates neuropathic pain in mice

Year Published: 2014

Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method ...
EAR - CANCER

Hydrogen protects auditory hair cells from cisplatin-induced free radicals

Year Published: 2014

Cisplatin is a widely used chemotherapeutic agent for the treatment of various malignancies. However, its maximum dose is often limited by severe ototoxicity. Cisplatin ototoxicity may require the production of reactive oxygen species (ROS) in the inner ear by activating enzymes specific to the cochlea. Molecular hydrogen was recently established as an antioxidant that selectively reduces ROS, and ...
EAR - HEARING LOSS

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive ...

Year Published: 2014

Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We tested this hypothesis in guinea pigs with 0.5%, 1.0% and 1.5% H2 inhalation in air for 5h a day ...
SPINE - SPINAL CORD INJURY

Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord ...

Year Published: 2014

Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3, ...
BRAIN - SEPSIS

Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated ...

Year Published: 2014

To evaluate protective effects of inhaled hydrogen gas (H2) on cognitive function in a murine model of sepsis-associated encephalopathy (SAE). A total of 84 male ICR mice, weighing 20-25 g, aged 6-8 weeks, were randomly divided into 4 groups of sham, sham+H2, sepsis and sepsis+H2. Sepsis was established by cecal ligation and puncture (CLP). Mice in sham+H2 and sepsis+H2 groups received 2% H2 ...
BRAIN - SEPSIS

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via ...

Year Published: 2014

During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes and effective therapeutic strategies of brain injury in sepsis are still not fully clear. We designed this ...
BRAIN - TRAUMATIC BRAIN INJURY

Attenuation of diffuse axonal injury by intraperitoneal injection of hydrogen via reducing oxidative ...

Year Published: 2014

To investigate the role of oxidative stress in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI models. Methods Totally 118 adult male SD rats were divided into 3 groups with 39 in each: sham, DAI, and DAI + hydrogen treatment. Rat diffuse axonal injury was induced by an experimental facility, which was developed to make the rat head spin 90 degrees at the moment to cause ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in ...

Year Published: 2014

Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days ...
EYE - RETINAL INJURY

Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush

Year Published: 2014

Objective: To investigate the effect of molecular hydrogen (H2) in a rat model subjected to optic nerve crush (ONC). Methods: We tested the hypothesis that after optic nerve crush (ONC), retinal ganglion cell (RGC) could be protected by H₂. Rats in different groups received saline or hydrogen-rich saline every day for 14 days after ONC. Retinas from animals in each group underwent measurements ...
BRAIN - BRAIN INJURY

Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate ...

Year Published: 2014

Combination therapy of intracisternal (ic) infusion of magnesium sulfate solution and intravenous (iv) injection of hydrogen-enriched fluid can provide protection against delayed ischemic neurological deficits after subarachnoid hemorrhage (SAH). However, the effects of this therapy on physiological parameters in vivo remain unclear. In this study, the effects of combination therapy were ...
BRAIN - ENVIRONMENTAL POLLUTION

Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats

Year Published: 2014

Chronic exposure to low-levels of organophosphate (OP) compounds, such as chlorpyrifos (CPF), induces oxidative stress and could be related to neurological disorders. Hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. We explore whether intake of hydrogen-rich water (HRW) can protect Wistar rats from CPF-induced neurotoxicity. Rats were gavaged ...
EYE - RETINAL INJURY

Neuroprotective effects of saturated hydrogen water on retinal ganglion cells in rat optic nerve ...

Year Published: 2014

Objective: To investigate the protective effect of saturated hydrogen water on the retinal ganglion cells (RGC) of the rat optic nerve crush model. Design: Experimental study. Participants: Eighteen healthy adult male SD rats. Methods: Eighteen SD rats were randomly divided into the A, B and C group. There were 6 rats in each group. All the right eyes were selected as the experimental eyes, the ...
BRAIN - NEUROPROTECTION

Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit ...

Year Published: 2014

Background: Although NMDAR trafficking mediated by GSK-3β involvement in transmission of pronociceptive messages in the spinal cord has been confirmed by our previous studies, whether NMDAR trafficking is implicated in peripheral sensitization remains equivocal. It is demonstrated that inflammation is associated with spinal NMDAR-containing nociceptive neurons activation and the maintenance of ...
BRAIN - NEUROPROTECTION

Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via ...

Year Published: 2014

Remifentanil administration may subsequently cause paradoxical hyperalgesia in animals and humans, but mechanisms remain unclear. MnSOD nitration and inactivation caused by generation of reactive oxygen species and activation of NMDA receptors are involved in the induction and maintenance of central neuropathic pain. Hydrogen which selectively removes superoxide has gained much attention in recent ...