Research profile: Echo Refresh
Disclosure: Echo Water makes this product and funds Hydrogen Studies. The studies below were run by other researchers; we list them by a fixed rule so the count can be checked.
Of 116 human studies of breathing hydrogen gas, 18 report a hydrogen flow, or the percentage and total flow it can be worked out from, and 9 of those used 1,280 mL/min or less, within the hydrogen flow measured from the Echo Refresh. Of those 9, 5 improved their main outcome, 2 found no clear effect and 2 had mixed results. 98 studies did not report a flow that can be compared with a device and are not counted.
None of these studies tested an Echo product. They studied hydrogen gas at flows within this device's measured output. None of them was funded by Echo. 5 of 9 state their funding.
How this count is made
Human studies in the Hydrogen Studies database in which people breathed hydrogen gas at normal air pressure, and the paper reports a hydrogen flow at or below 1,280 mL per minute (the highest hydrogen flow H2 Analytics measured from the Echo Refresh). A flow counts when the authors state it, or when they state both the hydrogen percentage and the total gas flow (hydrogen flow = percentage × total flow). Studies that give only a percentage, such as 2% hydrogen in a mask, describe the air breathed rather than a device's output, so they are counted separately and never matched; so are diving and pressure-chamber studies. Animal and cell studies, and drinking, bathing and saline studies are excluded. A study's result is the direction of its primary outcome as recorded from the abstract and reviewed by our reviewer.
The matched studies (9)
This is a summary of published research, not medical advice. Hydrogen inhalation is not a treatment for any disease. How we review studies · How to compare hydrogen devices
Data version 391389b98a-H2A24020802, generated November 11, 2026.