Hydrogen-PQQ Combo Improves Memory and Brain Function in Seniors

Summary by Hydrogen Studies Editorial Team · Updated

Authors
Journal
The Journal of nutrition, health and aging
Year
DOI
10.1016/j.jnha.2024.100287
Study Type
Human
Outcome
Positive
Peer Reviewed
Yes
Country
Serbia
Health Condition
Mild Cognitive Impairment
Body System
Nervous System

TL;DR

A supplement containing dihydrogen and PQQ improved brain health markers and mental function in elderly people with mild cognitive problems.

Key Finding

Six weeks of dihydrogen-PQQ supplementation significantly increased serum BDNF levels and cerebral oxygen saturation while improving mental orientation in elderly individuals with mild cognitive impairment.

Summary

This study tested whether a six-week supplement containing hydrogen-producing minerals and a compound called PQQ could improve brain function and metabolism in 34 elderly people with mild memory problems. The supplement increased a brain-protective protein called BDNF, improved oxygen levels in the brain, and showed modest improvements in mental orientation (knowing where you are and what time it is), but the study was small and the improvements were modest.

Practical Takeaway

This small, short-term study suggests that dihydrogen-PQQ may support brain metabolism and orientation in older adults with cognitive decline, but the results are preliminary. The study included only 34 people over 6 weeks, so much larger and longer studies are needed before any health claims can be made. Anyone considering this supplement should consult their doctor first.

Abstract (excerpt)

Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment. Design: A parallel-group, randomized, placebo-controlled…

Read the full abstract via DOI