The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial

Anna Gvozdjakova, Branislav Kura, Ghizal Fatima, Jagdish P. Sharma, Jan Slezak, Kumar Kartikey, Mami Noda, Mohammad Arif Niaz, Ram B. Singh, Sergej M. Ostojic, Tyler W. LaBaron, Viliam Mojto

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DOI: 10.2147/DMSO.S240122 DOI is the universal ID for this study.

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Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis. Molecular hydrogen (H2) may attenuate oxidative stress, improve cellular function, and reduce chronic inflammation. Pre-clinical and clinical studies have shown promising effects of H2-rich water (HRW) on specific features of metabolic syndrome, yet the effects of long-term, high-concentration HRW in this prevalent condition remain poorly addressed.

Methods: We conducted a randomized, double-blinded, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to acquire baseline clinical data followed by randomization to either placebo or high-concentration HRW (> 5.5 millimoles of H2 per day) for 24 weeks.

Results: Supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo (P < 0.05). Furthermore, H2 tended to promote a mild reduction in body mass index and waist-to-hip ratio.

Conclusion: Our results give further credence that high-concentration HRW might have promising effects as a therapeutic modality for attenuating risk factors of metabolic syndrome.

Publish Year 2020
Country United States
Rank Positive
Journal Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Primary Topic Whole Body
Secondary TopicMetabolic Syndrome
Model Human
Tertiary TopicLipid Metabolism
Vehicle Water (Mg-Chemico)
pH Alkaline
Application Ingestion