Hydrogen Gas Reduces Hearing Loss From Noise in Guinea Pigs
The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs
Research hubs: Brain & Nervous System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (guinea pig)
- Authors
- Fereshte Bagheri, Akram Pourbakht, Ahmadreza Raisi, Mohammad Kamali, Mohammad Faridan
- Journal
- Health Scope
- Year
- 2018
- Study Type
- Guinea Pig
- Participants
- 12
- Delivery
- Gas
- H₂ concentration
- 2% H2 gas
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 1 (OpenAlex, as of November 2026)
- Country
- Iran
TL;DR
Breathing in hydrogen gas might help protect guinea pigs' hearing from damage caused by being exposed to loud noise and carbon monoxide at the same time.
Key Finding
Guinea pigs that inhaled hydrogen gas while exposed to noise and carbon monoxide showed significantly less hearing damage than those exposed to noise and carbon monoxide alone, particularly at higher frequencies.
Summary
Researchers exposed guinea pigs to noise and carbon monoxide together—a combination that can happen in some workplaces—and measured how this affected their hearing. When guinea pigs breathed in hydrogen gas along with the noise and carbon monoxide exposure, their hearing damage was reduced compared to animals that didn't receive hydrogen, especially at higher sound frequencies. The researchers believe hydrogen may work by reducing harmful molecules called free radicals that damage hearing structures.
Practical Takeaway
This is an early-stage animal study suggesting hydrogen inhalation may protect against hearing loss from combined noise and carbon monoxide exposure. However, this was only tested in guinea pigs over a short timeframe, so it's unclear whether these results would apply to humans or what dose and duration would be needed. More research, including human studies, would be necessary before drawing conclusions about practical use in occupational settings.
Abstract (excerpt)
Background: People might simultaneously be exposed to noise and carbon monoxide in occupational settings. The previous studies revealed that the inhalation of molecular hydrogen (H2) exerts some healing effects on multiple diseases including hearing loss. Objectives: The levels of free radicals…