Natural Hydrogen Waters Reduced Type 1 Diabetes Signs in Lab Tests
Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus
Research hubs: Endocrine System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (cell culture)
- Authors
- Yuping Li, Takeki Hamasaki, Kiichiro Teruya, Noboru Nakamichi, Zbigniew Gadek, Taichi Kashiwagi, Hanxu Yan, Tomoya Kinjo, Takaaki Komatsu, Yoshitoki Ishii, Sanetaka Shirahata
- Journal
- Cytotechnology
- Year
- 2011
- PMID
- 22143345
- Study Type
- Cell Culture
- Delivery
- Water, Commercial (Nordenau, Hita Tenryosui, Kagoshima)
- Dose
- Natural reduced waters administered for 8 weeks
- Duration
- 8 weeks
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 16 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Special types of water from Japan and Germany may help prevent diabetes by protecting insulin-producing cells from damage caused by harmful oxygen molecules.
Key Finding
Both Hita Tenryosui Water and Nordenau water suppressed alloxan-induced beta-cell death and prevented type 1 diabetes development in mice by reducing oxidative stress and restoring antioxidant enzyme activity.
Summary
This study tested two types of natural reduced waters (special waters with antioxidant properties) to see if they could protect insulin-producing cells from damage caused by alloxan, a chemical that triggers type 1 diabetes in mice. The researchers found that both waters reduced cell death, restored insulin levels, and lowered blood sugar in diabetic mice, apparently by reducing harmful molecules called reactive oxygen species and boosting the cells' natural defense systems.
Practical Takeaway
While these results are promising, they come from laboratory and animal studies only—not human trials. The findings suggest that certain natural reduced waters may help protect against oxidative stress-related diabetes, but much more research, including human studies, would be needed before drawing any conclusions about their use for diabetes prevention in people.
Abstract (excerpt)
Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells…