Suppression of glutamate-induced neural cell death by electrolyzed-reduced water

K. Otsubo, K. Teruya, M. Takaki, S. Kabayama, S. Morisawa, Sanetaka Shirahata, T. Hamasaki, Taichi Kashiwagi, Y. Katakura

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DOI: 10.1007/978-94-017-0726-8_18 DOI is the universal ID for this study.

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Electrolyzed-reduced water (ERW) produced by electrolyzing water in cathode side has the ability to scavenge reactive oxygen species (ROS). Here, we investigated the effect of ERW on oxidative stress-induced neural cell death by glutamate. When cell viability assay was performed using primary rat cerebral cortical culture as neural model, ERW suppressed neural cell death by glutamate. Furthermore, intracellular ROS levels were reduced by ERW, suggesting that suppressive effect of ERW on the glutamate-induced neural cell death was due to the suppression of glutamate-induced ROS augmentation by ERW.

Publish Year 2003
Country Japan
Rank Positive
Journal Animal Cell Technology: Basic and Applied Aspects
Primary Topic Brain
Secondary TopicNeuroprotection
Model Cell Culture
Tertiary TopicExcitotoxicity
Vehicle Water (Electrolysis)
pH Alkaline
Application Culture Media