Hydrogen Gas Solubility in Lab Blood and Muscle Tissue

Researchers measured how well different gases dissolve in water, saltwater, dog blood, and muscle tissue at body temperature, finding that blood can hold varying amounts of these gases, with some gases dissolving better in fatty substances.

Hydrogen gas dissolves similarly in dog blood and muscle tissue, with distribution ratios near 1.0, suggesting uniform distribution across these tissue types.

Researchers measured how well hydrogen gas (H2) and three other inert gases dissolve in dog blood, muscle tissue, and other fluids at body temperature. They found that hydrogen, argon, and methane dissolve similarly across different tissue types, while sulfur hexafluoride (a different gas) dissolved much better in fatty tissues. This basic information about how gases distribute in the body could help scientists understand how therapeutic gases move through tissues.

This is a fundamental laboratory study in dogs that measures basic gas solubility—not a test of hydrogen water's health effects. While the data on hydrogen's tissue distribution may eventually inform how hydrogen is delivered therapeutically, this study alone tells us nothing about whether hydrogen water provides health benefits to humans.

Solubility of H2, Ar, CH4 and SF6 was determined at 310 K (37 degrees C) in water, in saline (0.154 mol NaCl/l H2O), in plasma and whole blood of dogs, and in homogenates of the dog gastrocnemius muscle. The liquids were equilibrated with pure gases, and the dissolved gases were extracted…

Read the full abstract on PubMed