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Hydrogen Therapy Protects Heart from Damage During Heart Attacks

Protective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury

Research hubs: Cardiovascular System

Scientific visualization of hydrogen therapy research for Protective Mechanism and Clinical Application of Hydrogen in Myocardial Ischemia-reperfusion Injury
Evidence type
Review or commentary
Authors
Liangtong Li, Xiangzi Li, Zhe Zhang, Li Liu, Yujuan Zhou, Fulin Liu
Journal
Pakistan Journal of Biological Sciences
Year
2020
Study Type
clinical
Outcome
positive
Peer Reviewed
Yes
Cited by
21 (OpenAlex, as of November 2026)
Country
China

TL;DR

Scientists found that hydrogen gas can protect heart cells from damage that happens when blood flow is restored after a heart attack, by fighting off harmful chemicals and reducing swelling—which could be a new way to treat heart disease and save lives.

Key Finding

Hydrogen acts as a selective antioxidant that may protect heart tissue from ischemia-reperfusion injury through free radical neutralization, anti-apoptotic effects (preventing cell death), and anti-inflammatory mechanisms.

Summary

This is a review article that examines how hydrogen gas may protect heart tissue from damage that occurs when blood flow is restored after a heart attack. The authors explain that hydrogen works by neutralizing harmful molecules called free radicals and reducing inflammation, and they discuss how this approach might be used clinically to improve outcomes for heart disease patients.

Practical Takeaway

This is a review of existing research rather than a new study with human subjects, so it summarizes potential rather than proven benefits. While early evidence suggests hydrogen may have protective effects in heart tissue, most research to date has been in laboratory or animal settings. More human clinical trials would be needed to determine whether hydrogen water or hydrogen gas has meaningful therapeutic value for heart disease patients.

Abstract (excerpt)

Cardiovascular disease accounts for one-third of all deaths, with ischemic heart disease as the main cause of death. Under pathological conditions, ischemia-reperfusion injury (IRI) often occurs in tissues. Ischemic injury is mainly caused by anaerobic cell death and reperfusion which results…

Read the full abstract on PubMed