Hydrogen Therapy Shows Promise for Lung Transplant Complications

Scientists found that hydrogen gas can protect donated lungs from damage during transplant surgery by reducing harmful inflammation and oxidative stress, and it can be given to patients through breathing it in, drinking special water, or injections. This is really promising because lung transplants often fail due to this kind of damage, but we need to test it more in real patients before doctors can start using it regularly.

Animal studies suggest molecular hydrogen reduces lung damage during transplantation by decreasing inflammation and oxidative stress, but human clinical evidence is not yet available.

This review examined research on whether molecular hydrogen (H2)—a simple gas—can protect lung tissue during transplant surgery. Studies in animals showed that hydrogen, given through breathing, drinking hydrogen-rich water, or injection, reduced damage to transplanted lungs by decreasing harmful inflammation and oxidative stress (cellular damage from unstable molecules). However, the exact way hydrogen works in the body is not fully understood, and human studies are still needed.

While early animal research indicates hydrogen may help protect transplanted lungs, this is a review of laboratory studies, not human trials. Anyone considering hydrogen as a transplant-related treatment should wait for clinical trials in humans and consult their transplant team, as the protective effects have not been proven in patients.

Lung grafts may experience multiple injuries during lung transplantation, such as warm ischaemia, cold ischaemia, and reperfusion injury. These injuries all contribute to primary graft dysfunction, which is a major cause of morbidity and mortality after lung transplantation. As a potential…

Read the full abstract on PubMed