Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice

Hye Kyung Kim, Kang-Hyun Leem, Kyung Hee Jung, Mi-Ja Kim, Yoon Kyung Uhm

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DOI: 10.1248/bpb.30.234 DOI is the universal ID for this study.

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Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic beta-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved beta-cell mass in db/db mice. The present data suggest that ERW may protects beta-cell damage and would be useful for antidiabetic agent.

Publish Year 2007
Country South Korea
Rank Positive
Journal Biological and Pharmaceutical Bulletin
Primary Topic Pancreas
Secondary TopicDiabetes (Type II)
Model Mouse
Tertiary TopicGlucose Metabolism
Vehicle Water (Electrolysis)
pH Alkaline
Application Ingestion