New Treatment Combo Shows Promise for Advanced Parkinson's Disease
- Authors
- G Niraj, N Charan, Shruti Niraj, Varsha B Karanth, Lakshmanan Prakash
- Journal
- Cureus
- Year
- 2026
- DOI
- 10.7759/cureus.101146
- Study Type
- Human
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- India
- Health Condition
- Parkinson's Disease
- Body System
- Nervous System
TL;DR
A small case series reported improved symptoms and quality of life in advanced Parkinson’s disease patients following a multimodal precision health program.
Summary
This case series described three patients with advanced idiopathic Parkinson’s disease who underwent a 12-week precision health optimization program that included dual stellate ganglion block, nutraceutical infusions, and extracorporeal blood ozone therapy. The intervention aimed to address autonomic imbalance, oxidative stress, neuroinflammation, and mitochondrial dysfunction—processes implicated in Parkinson’s disease pathophysiology. At 12 weeks, all patients reported reduced disease severity and improved quality of life based on validated outcome measures. However, the findings are limited by the very small sample size, lack of a control group, and potential placebo effects, and therefore require confirmation in controlled clinical trials.
Abstract (excerpt)
Parkinson's disease (PD) is reported to be the fastest-growing neurodegenerative condition with significant management challenges. Neurobiology is linked to mitochondrial dysfunction, oxidative stress, autonomic imbalance, and neuroinflammation. There is progressive propagation of alpha-synuclein…