Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy

Boyu Zhang, Changfeng Wu, Duyang Gao, Fei Wang, Hua Zhou, Xuanjun Zhang, Zhen Yuan

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DOI: 10.1002/anie.201813066 DOI is the universal ID for this study.

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Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. A liposome was employed as a nanoreactor to confine the Pdot photocatalyst, reactants, intermediates, and by‐products. Upon photon absorption by the Pdots, the catalytic cycle is initiated and repeated within the aqueous interior, while the H2 product diffuses across the lipid bilayer to counteract reactive oxygen species (ROS) overexpressed in diseased tissues. Ensemble and single‐particle Förster resonance energy transfer microscopy confirmed the proposed nanoreactor model. We demonstrate that a liposomal nanoreactor containing Pdots and a sacrificial electron donor is a potential photocatalytic nanoreactor for in situ hydrogen therapy.

Publish Year 2019
Country China
Rank Positive
Journal Angewandte Chemie International Edition
Primary Topic Whole Body
Secondary TopicROS-Scavenging
Model Cell Culture
Tertiary TopicNovel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Implantation