Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy
Boyu Zhang, Changfeng Wu, Duyang Gao, Fei Wang, Hua Zhou, Xuanjun Zhang, Zhen Yuan
Read more:
DOI:
10.1002/anie.201813066
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. A liposome was employed as a nanoreactor to confine the Pdot photocatalyst, reactants, intermediates, and by‐products. Upon photon absorption by the Pdots, the catalytic cycle is initiated and repeated within the aqueous interior, while the H2 product diffuses across the lipid bilayer to counteract reactive oxygen species (ROS) overexpressed in diseased tissues. Ensemble and single‐particle Förster resonance energy transfer microscopy confirmed the proposed nanoreactor model. We demonstrate that a liposomal nanoreactor containing Pdots and a sacrificial electron donor is a potential photocatalytic nanoreactor for in situ hydrogen therapy.
| Publish Year |
2019 |
| Country |
China |
| Rank |
Positive |
| Journal |
Angewandte Chemie International Edition |
| Primary Topic |
Whole Body |
| Secondary Topic | ROS-Scavenging |
| Model |
Cell Culture |
| Tertiary Topic | Novel Therapy |
| Vehicle |
Gas (Sustained Release) |
| pH |
N/A |
| Application |
Implantation |
| Comparison |
|
| Complement |
|
NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions ...
2023 - Whole Body - Immune Regulation
Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits its clinical outcomes. ...
Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy
2023 - Whole Body - Sepsis
Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti-inflammation or anti-infection treatment exhibits ...
Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium ...
2023 - Whole Body - Metabolic Syndrome
Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is ...
Antioxidation activity of molecular hydrogen via protoheme catalysis in vivo: an insight from ab ...
2022 - Whole Body - ROS-Scavenging
Recently, molecular hydrogen has been found to exhibit antioxidation activity through many clinical experiments, but the mechanism has not been fully understandable at atomic level. In this work, we perform systematic ab initio calculations of ...
Enhanced Removal of Free Radicals by Aqueous Hydrogen Nanobubbles and Their Role in Oxidative Stress
2022 - Whole Body - ROS-Scavenging
Elevated levels of reactive oxygen radicals caused by environmental stress are the key triggers of inflammation, aging, and disease; thus, it is critical to develop novel reactive oxygen radical scavenging methods with high efficiency and low ...
Magnesium Particles Coated with Mesoporous Nanoshells as Sustainable Therapeutic-Hydrogen Suppliers ...
2018 - Whole Body - ROS-Scavenging
Sustainable supplementation of massive molecular‐H2 is considered to be the most effective therapy for long‐term elimination of excessive hydroxyl radicals (·OH) in vivo, but has not been achieved so far. In this work, it is demonstrated that ...