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Hydrogen-Oxygen Gas Shows Promise for COVID-19 and Lung Disease

Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and Sustainable Treatment for COVID-19 and Other Respiratory Diseases

Research hubs: Respiratory System

Scientific visualization of hydrogen therapy research for Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and Sustainable Treatment for COVID-19 and Other Respiratory Diseases
Evidence type
Review or commentary
Authors
Grace Russell, Alexander Nenov, John T. Hancock
Journal
European Medical Journal
Year
2021
Study Type
clinical
Delivery
inhalation
H₂ concentration
66% H2 in 2:1 ratio with oxygen (HHO gas mixture)
Peer Reviewed
Yes
Cited by
18 (OpenAlex, as of November 2026)
Country
United Kingdom

TL;DR

Scientists are testing a new gas mixture made from hydrogen and oxygen that might help treat COVID-19 and other lung diseases by reducing swelling and damage in the lungs, but there isn't enough evidence yet to prove it actually works.

Key Finding

Oxy-hydrogen gas is proposed as an emerging therapy for respiratory diseases based on theoretical mechanisms involving reduced oxidative stress and decreased inflammation, but the authors acknowledge a significant lack of scientific evidence supporting its clinical use.

Summary

This article reviews oxy-hydrogen gas (HHO)—a mixture of hydrogen and oxygen created by passing electricity through water—as a potential treatment for respiratory diseases like COVID-19. The authors explain that HHO may help by reducing oxidative stress (cellular damage from unstable molecules) and calming inflammation in the lungs. However, they acknowledge that very little scientific evidence currently supports this approach and call for more rigorous testing.

Practical Takeaway

This is a review article outlining a theoretical concept rather than reporting new research findings. While the proposed mechanisms are scientifically plausible, there is currently insufficient clinical evidence to support HHO as an established treatment for COVID-19 or other respiratory diseases. Anyone considering this therapy should await results from rigorous clinical trials before use.

Abstract (excerpt)

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen and molecular oxygen that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of noninvasive inhalation devices such as nasal cannulas or nebulisers. Although there…

Read the full abstract via DOI