Hydrogen-Oxygen Gas Shows Promise for COVID-19 and Lung Disease
- Authors
- Grace Russell, Alexander Nenov, John T. Hancock
- Journal
- European Medical Journal
- Year
- 2021
- DOI
- 10.33590/emj/21-00027
- Study Type
- clinical
- Peer Reviewed
- Yes
- Country
- United Kingdom
- Health Condition
- COVID-19
- Body System
- Respiratory
TL;DR
Scientists are testing a new gas mixture made from hydrogen and oxygen that might help treat COVID-19 and other lung diseases by reducing swelling and damage in the lungs, but there isn't enough evidence yet to prove it actually works.
Key Finding
Oxy-hydrogen gas is proposed as an emerging therapy for respiratory diseases based on theoretical mechanisms involving reduced oxidative stress and decreased inflammation, but the authors acknowledge a significant lack of scientific evidence supporting its clinical use.
Summary
This article reviews oxy-hydrogen gas (HHO)—a mixture of hydrogen and oxygen created by passing electricity through water—as a potential treatment for respiratory diseases like COVID-19. The authors explain that HHO may help by reducing oxidative stress (cellular damage from unstable molecules) and calming inflammation in the lungs. However, they acknowledge that very little scientific evidence currently supports this approach and call for more rigorous testing.
Practical Takeaway
This is a review article outlining a theoretical concept rather than reporting new research findings. While the proposed mechanisms are scientifically plausible, there is currently insufficient clinical evidence to support HHO as an established treatment for COVID-19 or other respiratory diseases. Anyone considering this therapy should await results from rigorous clinical trials before use.
Abstract
Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen and molecular oxygen that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of noninvasive inhalation devices such as nasal cannulas or nebulisers. Although there is a paucity of scientific evidence supporting this new and emerging therapy, initial investigations indicate that HHO proffers cytoprotective qualities, typically by reducing oxidative stress and attenuating the inflammatory response. These aspects are particularly favourable when considering respiratory medicine because underlying inflammation is known to drive the pathological progress of numerous respiratory conditions, including asthma, chronic obstructive pulmonary disorder, and, pertinently, coronavirus disease (COVID-19). Direct delivery to the lung parenchyma is also likely to increase the effectiveness of this emerging medical therapy. This narrative review aims to delineate how this particular combination of gases can affect cellular processes at the molecular level by focussing on the evolutionary requirement for both oxygen and hydrogen. Furthermore, the authors assess the current available data for the safety and efficacy of HHO in a clinical setting.