Hydrogen Water Reduced Oxalate-Induced Kidney Injury in Mice
Oral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Yachen Si, Lulu Liu, Jin Cheng, Tingting Zhao, Qi Zhou, Jianpeng Yu, Wei Chen, Jiarong Ding, Xuejun Sun, Hongtao Lu, Zhiyong Guo
- Journal
- Frontiers in Medicine
- Year
- 2021
- PMID
- 34490303
- Study Type
- Mouse
- Delivery
- Water (Electrolysis)
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
TL;DR
Drinking hydrogen-rich water (HRW) may help protect against kidney damage caused by too much oxalate, a substance found in certain foods.
Key Finding
In mice with oxalate-induced kidney injury, hydrogen-rich water reduced crystal deposition, kidney tissue damage, inflammation, and oxidative stress by suppressing three cellular signaling pathways (PI3K/AKT, NF-κB, and TGF-β).
Summary
Researchers gave mice with kidney damage from a high-oxalate diet (which causes calcium oxalate crystal buildup in kidneys) hydrogen-rich water or regular water. Mice receiving hydrogen-rich water showed less crystal buildup, less kidney tissue damage, and reduced markers of inflammation and oxidative stress (cellular damage from unstable molecules) in their blood and kidney tissue compared to controls.
Practical Takeaway
This is an early-stage animal study that suggests hydrogen-rich water may help protect against kidney damage from high oxalate levels, but results from mouse studies do not automatically translate to humans. Human clinical trials would be needed to determine whether hydrogen-rich water offers similar benefits for people at risk of kidney stones or oxalate-related kidney disease.
Abstract (excerpt)
Objective: To explore the theraputic effects and potential mechanisms of hydrogen-rich water (HRW) against oxalate-induced kidney injury.Methods: The mouse model of Calcium oxalate (CaOx) crystallization was established by feeding a soluble oxalate diet. Crystal deposition, tubular injury, fibrosis…