Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats
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DOI:
10.2147/NDT.S138289
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Abstract:
Background: In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis.
Materials and methods: Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests. Before and after administration of natural reduced or distilled water, we performed blood and urine analyses.
Results: Natural reduced water exhibited anxiolytic-like effects in the conditioned fear and elevated plus maze tests. The mean levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the natural reduced water were significantly lower than the distilled water group. Natural reduced water group also showed decrease in blood-urea nitrogen levels compared with the distilled water group.
Conclusion: These results indicate that natural reduced water may decrease anxiety-related behaviors and prevent heightened oxidative stress.
| Publish Year | 2017 |
|---|---|
| Country | Japan |
| Rank | Positive |
| Journal | Neuropsychiatric Disease and Treatment |
| Primary Topic | Brain |
| Secondary Topic | Anxiety |
| Model | Rat |
| Tertiary Topic | Oxidative Stress |
| Vehicle | Water, Commercial (Hita Tenryosui) |
| pH | Alkaline |
| Application | Ingestion |
| Comparison | |
| Complement |