Nano-Bubble Hydrogen Water and Viral Inflammation in Zebrafish
Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model
Research hubs: Immune System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (zebrafish)
- Authors
- Chen Li, Yiran Cao, Fukuda Kohei, Haihong Hao, Guiqing Peng, Can Cheng, Jing Ye
- Journal
- Virologica Sinica
- Year
- 2022
- PMID
- 35249853
- Study Type
- Zebrafish
- Delivery
- Water (Dissolved)
- H₂ concentration
- 0.7 ppm
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 25 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Nano-bubble hydrogen water significantly reduces the harmful effects of a virus in zebrafish, including lowering death rates and inflammation.
Key Finding
Nano-bubble hydrogen water reduced mortality by 40% in virus-infected zebrafish and significantly decreased viral replication, tissue damage, and inflammatory markers.
Summary
Researchers tested a special type of hydrogen water called nano-bubble hydrogen water on fish infected with a virus to see if it could reduce inflammation and tissue damage. The hydrogen water reduced death rates by 40% in infected fish, slowed virus spread, decreased harmful molecules called reactive oxygen species, and lowered inflammatory proteins. This early-stage study suggests hydrogen water may help fight viral infections by reducing the body's inflammatory response.
Practical Takeaway
While these results are promising, this is an early-stage study in fish, not humans. The findings suggest nano-bubble hydrogen water may have anti-inflammatory and antiviral potential, but much more research—including human studies—would be needed before any health claims could be made. The improved solubility of nano-bubble hydrogen water compared to regular hydrogen water may make it more effective if similar benefits occur in humans, but this remains unproven.
Abstract (excerpt)
Since the anti-inflammatory effect of hydrogen has been widely known, it was supposed that hydrogen could suppress tissue damage by inhibiting virus-related inflammatory reactions. However, hydrogen is slightly soluble in water, which leads to poor effect of oral hydrogen-rich water therapy…