Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease

Akio Masuda, Ikuroh Ohsawa, Kinji Ohno, Masaaki Hirayama, Masafumi Ito, Masatoshi Ichihara, Mikako Ito, Satoshi Maesawa, Shigeo Ohta, Yasukazu Kajita, Yasunori Fujita, Yuan Fu, Yumi Suzuki

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DOI: 10.1016/j.neulet.2009.02.016 DOI is the universal ID for this study.

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Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. We examined effects of approximately 50%-saturated molecular hydrogen in drinking water before or after the stereotactic surgery on 6-hydroxydopamine-induced nigrostrital degeneration in a rat model of Parkinson's disease. Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. Tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease.

Publish Year 2009
Country Japan
Rank Positive
Journal Neuroscience Letters
Primary Topic Brain
Secondary TopicParkinson's Disease
Model Rat
Tertiary TopicNeurodegeneration
Vehicle Water, Commercial (Blue Mercury)
pH Neutral
Application Ingestion